Protocols for Dual Tracer PET/SPECT Preclinical Imaging.
Protocols for Dual Tracer PET/SPECT Preclinical Imaging.
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DOI：
10.3389/fphy.2020.00126
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发表时间：
2020-05-08
影响因子：
3.1
通讯作者：
Livieratos L
中科院分区：
文献类型：
--
作者：
Blower JE;Bordoloi JK;Rigby A;Farleigh M;Kim J;O'Brien H;Jackson J;Poyiatzis C;Bezer J;Sunassee K;Blower PJ;Livieratos L
多示踪剂PET/SPECT成像使得不同模态示踪剂能够同时存在，从而允许在短时间范围内对同一受试者的多个生理过程进行成像。氟-18和锝-99m，两种常用的PET和SPECT放射性核素，分别具有不同的发射曲线，提供了在另一种存在下成像的可能性。然而，每种放射性核素的存在对扫描另一种放射性核素的影响可能是显著的，并导致混淆结果。在这里，我们使用18F和99 mTc的组合来探索双示踪剂PET/SPECT成像所带来的挑战，并研究克服这些挑战的潜在实用方法。进行了混合放射性核素18F/99 mTc体模PET和SPECT成像实验，以确定每种放射性核素对使用Mediso nanoScan PET/CT和SPECT/CT小动物扫描仪进行的扫描的交叉效应。PET扫描图像质量和定量受到高于100 MBq的99 mTc活性的不利影响，这是由于高单次率增加了探测器的死时间。低于100 MBq 99 mTc时，PET扫描仪的定量准确性得以保留。由于511 keV光子的康普顿散射导致99 mTc活性的高估和噪声增加，18 F的存在对SPECT扫描图像质量和定量产生不利影响。然而，发现> 70：1的99 mTc：18F活性比完全减轻了对SPECT的这种影响。还探讨了康普顿散射的校正方法。可以设计注射序列和成像序列的合适组合以满足特定的实验性多示踪剂成像需要，每种放射性核素对另一种放射性核素的扫描只有微小或不显著的影响。
Multi-tracer PET/SPECT imaging enables different modality tracers to be present simultaneously, allowing multiple physiological processes to be imaged in the same subject, within a short time-frame. Fluorine-18 and technetium-99m, two commonly used PET and SPECT radionuclides, respectively, possess different emission profiles, offering the potential for imaging one in the presence of the other. However, the impact of the presence of each radionuclide on scanning the other could be significant and lead to confounding results. Here we use combinations of 18F and 99mTc to explore the challenges posed by dual tracer PET/SPECT imaging, and investigate potential practical ways to overcome them. Mixed-radionuclide 18F/99mTc phantom PET and SPECT imaging experiments were carried out to determine the crossover effects of each radionuclide on the scans using Mediso nanoScan PET/CT and SPECT/CT small animal scanners. PET scan image quality and quantification were adversely affected by 99mTc activities higher than 100 MBq due to a high singles rate increasing dead-time of the detectors. Below 100 MBq 99mTc, PET scanner quantification accuracy was preserved. SPECT scan image quality and quantification were adversely affected by the presence of 18F due to Compton scattering of 511 keV photons leading to over-estimation of 99mTc activity and increased noise. However, 99mTc:18F activity ratios of > 70:1 were found to mitigate this effect completely on the SPECT. A method for correcting for Compton scatter was also explored. Suitable combinations of injection sequence and imaging sequence can be devised to meet specific experimental multi-tracer imaging needs, with only minor or insignificant effects of each radionuclide on the scan of the other.
影响因子：
12.4
作者：
Man, Francis;Lim, Lindsay;de Rosales, Rafael T. M.
通讯作者：
de Rosales, Rafael T. M.
DOI：
10.1016/0735-1097(95)00295-6
发表时间：
1995-10-01
影响因子：
24
作者：
SANDLER, MP;VIDELEFSKY, S;OHANA, I
通讯作者：
OHANA, I
影响因子：
9.3
作者：
Szanda, Istvan;Mackewn, Jane;Marsden, Paul K.
通讯作者：
Marsden, Paul K.