Fat Consumption Attenuates Cortical Oxygenation during Mental Stress in Young Healthy Adults.
Fat Consumption Attenuates Cortical Oxygenation during Mental Stress in Young Healthy Adults.
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DOI：
10.3390/nu15183969
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发表时间：
2023-09-14
期刊：
影响因子：
5.9
通讯作者：
Rendeiro C
中科院分区：
文献类型：
--
作者：
Baynham R;Lucas SJE;Weaver SRC;Veldhuijzen van Zanten JJCS;Rendeiro C
精神压力与心血管事件和中风有关，并且还与大脑功能较差有关，这可能是由于它对脑血管系统的影响。在压力期间，人们常常会增加不健康食物的摄入量，尤其是高脂肪食物。众所周知，高脂肪摄入和精神压力都会损害内皮功能，但很少有研究调查精神压力期间脂肪消耗对脑血管结局的影响。因此，这项研究研究了在精神压力任务之前吃高脂肪早餐是否会改变年轻健康成年人的皮质氧合和颈动脉血流量。在一项随机、平衡、交叉、餐后干预研究中，21 名健康男性和女性在进行 8 分钟精神压力任务前 1.5 小时摄入高脂肪（56.5 克脂肪）或低脂肪（11.4 克脂肪）早餐。在餐前基线、餐后 1 小时 15 分钟休息时以及应激后 10、30 和 90 分钟评估颈总动脉 (CCA) 直径和血流量。在餐后休息和压力期间评估前额皮质（PFC）组织氧合（近红外光谱，NIRS）和心血管活动。精神压力会增加心率、收缩压和舒张压以及 PFC 组织氧合。重要的是，高脂肪早餐减少了压力引起的 PFC 组织氧合作用的增加，尽管高脂肪和低脂肪膳食之间的心血管反应没有差异。脂肪和压力对静息 CCA 血流没有影响，而两餐后 CCA 直径增加。这是第一项表明年轻健康成年人在压力发作期间脂肪消耗可能损害 PFC 灌注的研究。鉴于在压力期间食用高脂肪食物的普遍性，这些发现对于未来探索精神压力期间食物选择与脑血流动力学之间关系的研究具有重要意义。
Mental stress has been associated with cardiovascular events and stroke, and has also been linked with poorer brain function, likely due to its impact on cerebral vasculature. During periods of stress, individuals often increase their consumption of unhealthy foods, especially high-fat foods. Both high-fat intake and mental stress are known to impair endothelial function, yet few studies have investigated the effects of fat consumption on cerebrovascular outcomes during periods of mental stress. Therefore, this study examined whether a high-fat breakfast prior to a mental stress task would alter cortical oxygenation and carotid blood flow in young healthy adults. In a randomised, counterbalanced, cross-over, postprandial intervention study, 21 healthy males and females ingested a high-fat (56.5 g fat) or a low-fat (11.4 g fat) breakfast 1.5 h before an 8-min mental stress task. Common carotid artery (CCA) diameter and blood flow were assessed at pre-meal baseline, 1 h 15 min post-meal at rest, and 10, 30, and 90 min following stress. Pre-frontal cortex (PFC) tissue oxygenation (near-infrared spectroscopy, NIRS) and cardiovascular activity were assessed post-meal at rest and during stress. Mental stress increased heart rate, systolic and diastolic blood pressure, and PFC tissue oxygenation. Importantly, the high-fat breakfast reduced the stress-induced increase in PFC tissue oxygenation, despite no differences in cardiovascular responses between high- and low-fat meals. Fat and stress had no effect on resting CCA blood flow, whilst CCA diameter increased following consumption of both meals. This is the first study to show that fat consumption may impair PFC perfusion during episodes of stress in young healthy adults. Given the prevalence of consuming high-fat foods during stressful periods, these findings have important implications for future research to explore the relationship between food choices and cerebral haemodynamics during mental stress.
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影响因子：
3.7
作者：
Brindle, Ryan C.;Ginty, Annie T.;Lucas, Samuel J. E.
通讯作者：
Lucas, Samuel J. E.
影响因子：
64.8
作者：
Gordon GR;Choi HB;Rungta RL;Ellis-Davies GC;MacVicar BA
通讯作者：
MacVicar BA
影响因子：
6.3
作者：
Ayata, Cenk;Shin, Hwa Kyoung;Huang, Paul L.
通讯作者：
Huang, Paul L.
影响因子：
7.1
作者：
Frank, Sabine;Linder, Katarzyna;Veit, Ralf
通讯作者：
Veit, Ralf
DOI：
10.1073/pnas.0807041106
发表时间：
2009-01-20
影响因子：
11.1
作者：
Liston, C.;McEwen, B. S.;Casey, B. J.
通讯作者：
Casey, B. J.