Hyperthermia-Induced Neuronal Protection against Ischemic Injury in Gerbils
Hyperthermia-Induced Neuronal Protection against Ischemic Injury in Gerbils
复制标题
热疗诱导的沙鼠神经元对缺血性损伤的保护
DOI：
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发表时间：
1991
影响因子：
6.3
通讯作者：
T. Kamada
中科院分区：
文献类型：
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作者：
K. Kitagawa;M. Matsumoto;M. Tagaya;K. Kuwabara;Ryuji Hata;Nobuo Handa;R. Fukunaga;K. Kimura;T. Kamada
我们采用沙土鼠前脑缺血5分钟模型，研究了在诱导脑缺血前热预处理的影响。缺血前18h单次热疗具有部分保护作用，缺血前18h重复热预处理对海马神经元死亡有明显保护作用，而缺血前3、6、24、50h单次热疗对神经元死亡无明显保护作用。高温预处理的这种短暂和累积的神经保护作用强烈地表明，高温后的应激反应参与了对缺血性神经元死亡的保护机制。
We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.
DOI：
10.1073/pnas.79.10.3218
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
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作者：
LI, GC;WERB, Z
通讯作者：
WERB, Z
影响因子：
56.9
作者：
RIABOWOL, KT;MIZZEN, LA;WELCH, WJ
通讯作者：
WELCH, WJ