Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents.
Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents.
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DOI：
10.1111/j.1469-7610.2009.02201.x
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Hommer DW
中科院分区：
文献类型：
--
作者：
Bjork JM;Chen G;Smith AR;Hommer DW
外化障碍的对手过程理论（ExD）将其归因于过度活跃的奖励处理系统和/或不活跃的受损行为抑制系统的某种组合。包括伏隔核（NAcc）在内的腹侧纹状体（VS）的激励-动机神经回路已被编入奖励处理的索引。我们使用功能性磁共振成像（fMRI）和激励任务来确定青春期外化症状是否与通过奖励提示或奖励交付增强的VS招募相关。12名社区招募的外化障碍（AED）青少年和12名年龄/性别匹配的对照组对赢得或避免损失0美元、0.20美元、1美元、5美元或未知金额（0.20美元至5美元）的目标做出反应。对奖励作出反应的线索激活了NAcc（相对于没有激励的线索），在两个被试组中都是一样的，最大奖励的线索调动了最多的NAcc。在兴趣量分析中检测到预期损失的NAcc信号增加，但这种增加只发生在受试者达到目标的试验中。与对照组相比，AED表现出显著升高的NAcc激活，这是奖励通知与未能获得奖励通知之间的线性对比。在事后的再分析中，VS和产前前扣带激活的奖励与非奖励结果对比也与儿童行为检查表（CBCL）外化总分（所有受试者）直接相关，而不是二元诊断。最后，两组都表现出被损失通知激活的右脑岛（与避免损失相比）。外化行为，无论是用问卷量表进行评估，还是以诊断分类的形式进行评估，都与对奖励导向行为结果的夸张边缘反应有关。这可能是外化症状儿童对实验室奖励传递的行为敏感性的神经生物学特征。我们感兴趣的是未来对更严重的、临床提及的AED的激励-动机加工的研究。
Opponent-process theories of externalizing disorders (ExD) attribute them to some combination of overactive reward processing systems and/or underactive impaired behavior inhibition systems. Reward processing has been indexed by recruitment of incentive-motivational neurocircuitry of the ventral striatum (VS), including nucleus accumbens (NAcc). We used functional magnetic resonance imaging (fMRI) with an incentive task to determine whether externalizing symptomatology in adolescence is correlated with an enhanced VS recruitment by cues for rewards, or by deliveries of rewards. Twelve community-recruited adolescents with externalizing disorders (AED) and 12 age/gender-matched controls responded to targets to win or avoid losing $0, $0.20, $1, $5, or an unknown amount (ranging from $0.20–$5). Cues to respond for rewards activated the NAcc (relative to cues for no incentive), in both subject groups similarly, with greatest NAcc recruitment by cues for the largest reward. Loss-anticipatory NAcc signal increase was detected in a volume-of-interest analysis- but this increase occurred only in trials when subjects hit the target. Relative to controls, AED showed significantly elevated NAcc activation by a linear contrast between reward notification versus notification of failure to win reward. In a post hoc reanalysis, VS and pregenual anterior cingulate activation by the reward versus nonreward outcome contrast also directly correlated with Child Behavior Checklist (CBCL) Externalizing total scores (across all subjects) in lieu of a binary diagnosis. Finally, both groups showed right insula activation by loss notifications (contrasted with avoided losses). Externalizing behavior, whether assessed dimensionally with a questionnaire, or in the form of a diagnostic categorization, is associated with an exaggerated limbic response to outcomes of reward-directed behavior. This could be a neurobiological signature of the behavioral sensitivity to laboratory reward delivery that is characteristic of children with externalizing symptomatology. Of interest is future research on incentive-motivational processing in more severe, clinically-referred AED.
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DOI：
10.1007/0-306-47148-5_10
发表时间：
1998-01-01
期刊：
RECENT DEVELOPMENTS IN ALCOHOLISM, VOL 14
影响因子：
--
作者：
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通讯作者：
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影响因子：
3.6
作者：
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影响因子：
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作者：
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DOI：
10.1111/j.1530-0277.1995.tb01019.x
发表时间：
1995-12-01
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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作者：
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