Determination of No-Observed-Adverse-Effect Level Ammonia in White Mice Through CD4 Expression.
Determination of No-Observed-Adverse-Effect Level Ammonia in White Mice Through CD4 Expression.
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DOI：
10.1177/1559325818807790
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Maharja R
中科院分区：
文献类型：
--
作者：
Tualeka AR;Faradisha J;Maharja R
氨是一种能对工人造成急性和慢性影响的化合物。本研究的目的是确定氨在小白鼠体内的无观察不良反应水平（NOAEL）。本研究以小白鼠为对象，采用室内实验设计，后验组设计。寻找安全限度的过程从确定对小白鼠无效的氨的最高剂量和最低剂量开始。最新研究表明，无作用的最高剂量为0.0456 mg/kg，最低剂量为0.0046 mg/kg。在确定了氨的最高和最低剂量后，研究人员开始确定中间剂量。中剂量是从最低剂量开始乘1.5的最高剂量和最低剂量之间的剂量（5个中浓度变化有5个中剂量变化），包括0.0872、0.1309、0.1963、0.2944和0.4416 mg/m3。从无作用的中剂量和最低剂量的结果，发现无作用的最高NH3剂量值，显示IRS降低前的最高Remmele量表（IRS） CD4。研究得出，小白鼠体内氨的NOAEL值为0.0103 mg/kg体重。
Ammonia is one of the chemical compounds that can cause acute and chronic effects to the workers. The purpose of this study is to determine the no-observed-adverse-effect level (NOAEL) ammonia in white mice. This study applied a laboratory experimental with design post test-only control group design using white mice as an object. The process of finding the safe limit began by determining the highest dose and the lowest dose of ammonia without effect in white mice. The latest research showed that the highest dose without effect is 0.0456 mg/kg and the lowest dose without effect is 0.0046 mg/kg. After determining the highest and the lowest dose of ammonia, the researcher started to determine the middle dose. The middle dose is the dose between the highest and the lowest doses with the multiplication of 1.5 starting from the lowest dose (there are 5 middle-dose variations from 5 middle concentration variations), consisting of 0.0872, 0.1309, 0.1963, 0.2944, and 0.4416 mg/m3. From the result of the middle dose and the lowest dose without effect, it is found the value of the highest NH3 dose without effect, which showed the highest Index Remmele Scale (IRS) CD4 before the reduction of IRS. The study concludes that the NOAEL of ammonia contained in white mice is 0.0103 mg/kg body weight of the mice.
影响因子：
2.1
作者：
Perkins, Michael W.;Wong, Benjamin;Sciuto, Alfred M.
通讯作者：
Sciuto, Alfred M.
影响因子：
4.7
作者：
Liu, CH;Chen, JC
通讯作者：
Chen, JC