Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients.
Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients.
复制标题
胃炎患者中医证候网络生物标志物失衡
DOI：
10.1038/srep01543
复制
发表时间：
2013
影响因子：
4.6
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Li R;Ma T;Gu J;Liang X;Li S
寒证和热证是中医具有千年历史的关键治疗理念，它们描述了机体稳态的失衡。然而，由于当前还原论方法的局限性，中医证型的科学依据仍不明确。在此，我们建立了一个网络平衡模型来评估中医证型背后的失衡网络并寻找潜在的生物标志物。通过实施这一方法并对一组慢性浅表性胃炎（CSG）和慢性萎缩性胃炎（CAG）患者进行研究，我们发现以瘦素作为生物标志物，寒证患者的能量代谢水平较低，而CCL2/单核细胞趋化蛋白1（MCP1）这一生物标志物表明热证患者的免疫调节增强。这种代谢 - 免疫失衡网络在从慢性浅表性胃炎到慢性萎缩性胃炎的过程中是一致的。这项工作为科学地理解中医证型提供了一种新途径，进而有利于从古代医学和复杂生物系统的角度实现个性化医疗。
Cold Syndrome and Hot Syndrome are thousand-year-old key therapeutic concepts in traditional Chinese medicine (TCM), which depict the loss of body homeostasis. However, the scientific basis of TCM Syndrome remains unclear due to limitations of current reductionist approaches. Here, we established a network balance model to evaluate the imbalanced network underlying TCM Syndrome and find potential biomarkers. By implementing this approach and investigating a group of chronic superficial gastritis (CSG) and chronic atrophic gastritis (CAG) patients, we found that with leptin as a biomarker, Cold Syndrome patients experience low levels of energy metabolism, while the CCL2/MCP1 biomarker indicated that immune regulation is intensified in Hot Syndrome patients. Such a metabolism-immune imbalanced network is consistent during the course from CSG to CAG. This work provides a new way to understand TCM Syndrome scientifically, which in turn benefits the personalized medicine in terms of the ancient medicine and complex biological systems.
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DOI：
10.1073/pnas.011404098
发表时间：
2001-01-02
影响因子：
11.1
作者：
Li, C;Wong, WH
通讯作者：
Wong, WH
影响因子：
2.3
作者：
Li, S.;Zhang, Z. Q.;Wang, Y. Y.
通讯作者：
Wang, Y. Y.
影响因子：
12.3
作者：
Auffray C;Chen Z;Hood L
通讯作者：
Hood L
影响因子：
4.6
作者：
Jiang, Bai;Liang, Xujun;Chen, Yang;Ma, Tao;Liu, Liyang;Li, Junfeng;Jiang, Rui;Chen, Ting;Zhang, Xuegong;Li, Shao
通讯作者：
Li, Shao
影响因子：
82.9
作者：
Lawrence, T;Gilroy, DW;Willoughby, DA
通讯作者：
Willoughby, DA