Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients.
Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients.
复制标题
正常对照和癌症患者血清中血管内皮生长因子的浓度。
DOI：
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发表时间：
1996
影响因子：
11.5
通讯作者：
T. Tominaga
中科院分区：
文献类型：
--
作者：
Y. Yamamoto;M. Toi;S. Kondo;T. Matsumoto;Hideo Suzuki;M. Kitamura;K. Tsuruta;T. Taniguchi;A. Okamoto;T. Mori;Misao Yoshida;Takaaki Ikeda;T. Tominaga
血管内皮生长因子（VEGF）在肿瘤血管生成中起重要作用。我们已经调查了循环水平的VEGF在血清中的癌症患者以及从健康的正常对照使用敏感的酶免疫分析。在正常血清中可检测到免疫反应性VEGF蛋白，并且确定截止水平为180 pg/ml。在所有类型的癌症患者中，包括乳腺癌、胃肠癌、肝胆癌和肺癌，检测到VEGF循环水平异常升高。例如，在137例原发性乳腺癌患者中，12例（8.8%）显示VEGF水平异常升高。血清中VEGF的异常表达与疾病的进展以及肿瘤组织中VEGF蛋白的表达显著相关。此外，Western印迹分析证实了VEGF 165形式存在于复发性乳腺癌患者的血清中。得出的结论是，VEGF在正常血清中是可检测的，并且其水平在某些癌症患者群体中增加。作为一种正性血管生成调节因子，VEGF可能作为一种内分泌生长因子发挥作用，特别是对于实体瘤。
Vascular endothelial growth factor (VEGF) is known to play crucial roles in tumor angiogenesis. We have investigated the circulating level of VEGF in sera from cancer patients as well as from healthy normal controls using a sensitive enzymatic immunoassay. Immunoreactive VEGF proteins were detectable in normal sera, and the cutoff level was determined to be 180 pg/ml. In examined patients with all types of cancer, including breast, gastrointestinal, hepatobiliary, and lung cancer, an aberrant increase in the circulating level of VEGF was detected. For example, in 137 primary breast cancer patients, 12 (8.8%) showed an aberrant increase in VEGF levels. This aberrant expression of VEGF in sera was significantly associated with the progression of the disease, and with VEGF protein expression in tumor tissues. In addition, a Western blot analysis confirmed the presence of the VEGF165 form in sera from a patient with recurrent breast cancer. It was concluded that VEGF was detectable in normal sera, and its level was increased in some populations of cancer patients. A positive angiogenesis regulator, VEGF might function as an endocrine growth factor, particularly for solid tumors.
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DOI：
10.1111/j.1349-7006.2002.tb01302.x
发表时间：
2002-06
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Akutagawa N;Nishikawa A;Iwasaki M;Fujimoto T;Teramoto M;Kitajima Y;Endo T;Shibuya M;Kudo R
通讯作者：
Kudo R
影响因子：
158.5
作者：
WEIDNER, N;SEMPLE, JP;FOLKMAN, J
通讯作者：
FOLKMAN, J
DOI：
10.1093/jnci/86.5.356
发表时间：
1994-03-02
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
NGUYEN, M;WATANABE, H;FOLKMAN, J
通讯作者：
FOLKMAN, J
DOI：
10.1186/s12940-016-0123-2
发表时间：
2016-02-17
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Hooiveld M;Smit LAM;van der Sman-de Beer F;Wouters IM;van Dijk CE;Spreeuwenberg P;Heederik DJJ;Yzermans CJ
通讯作者：
Yzermans CJ
由同源二聚体 E2A-HLF 转录因子介导的细胞转化。
影响因子：
5.3
作者：
Inukai,T;Inaba,T;Yoshihara,T;Look,AT
通讯作者：
Look,AT