Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study.
Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study.
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在前瞻性病例 - 霍特分析中，外周血和乳腺癌风险的端粒长度：姐妹研究的结果。
DOI：
10.1007/s10552-011-9778-8
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发表时间：
2011-07
影响因子：
2.3
通讯作者：
Taylor, Jack A.
中科院分区：
文献类型：
--
作者：
Kim, Sangmi;Sandler, Dale P.;Carswell, Gleta;De Roo, Lisa A.;Parks, Christine G.;Cawthon, Richard;Weinberg, Clarice R.;Taylor, Jack A.
端粒是维持基因组完整性所必需的，可能在癌变中起作用。一些（但不是全部）流行病学研究发现，白细胞中的短端粒与乳腺癌风险增加有关。为了进一步阐明这种潜在的关联，我们从姐妹研究（Sister Study）前瞻性采集的血液样本中检测了端粒长度与乳腺癌风险的关系，该研究是一组年龄在35-74岁之间的女性，她们的姐妹患有乳腺癌。我们进行了病例队列分析，比较了2007年6月1日之前从29,026名参与者中随机抽取的乳腺癌病例（n=342）和一个亚队列（n=735）。使用单管单色多重定量PCR法估计外周血细胞的相对端粒长度。未观察到端粒长度与乳腺癌风险之间的关联。与最长四分位数相比，与第二、第三和最短四分位数相关的风险比（HR）分别为0.91（95%可信区间[95% CI]: 0.62-1.34）、1.11 （95% CI: 0.77-1.60）和0.93 （95% CI: 0.64-1.35）。绝经期状态、乳腺癌的侵袭性或雌激素受体状态的亚组分析没有显示血细胞端粒长度与随后的乳腺癌风险之间的关联证据。这项前瞻性研究不支持血细胞端粒长度作为乳腺癌风险的生物标志物。
Telomeres are required for maintaining genomic integrity and may play a role in carcinogenesis. Some, but not all, epidemiologic studies have found that short telomeres in leukocytes are associated with an increased risk of breast cancer. To further elucidate this potential association, we examined telomere length in relation to breast cancer risk in prospectively collected blood samples from the Sister Study, a cohort of women aged 35-74 years who have a sister with breast cancer. We performed a case-cohort analysis comparing incident breast cancer cases (n=342) with a subcohort (n=735), randomly selected from 29,026 participants enrolled by June 1, 2007. Relative telomere length in peripheral blood cells was estimated using a single tube monochrome multiplex quantitative PCR assay. No association was observed between telomere length and breast cancer risk. Compared to the longest quartile, hazard ratios (HR) associated with the second, third and the shortest quartile were 0.91 (95% confidence interval [95% CI]: 0.62-1.34), 1.11 (95% CI: 0.77-1.60) and 0.93 (95% CI: 0.64-1.35), respectively. Subgroup analyses by menopausal status, invasiveness or estrogen-receptor status of breast cancer did not reveal evidence of association between telomere length in blood cells and subsequent breast cancer risk. This prospective investigation does not support telomere length in blood cells as a biomarker for breast cancer risk.
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影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM
DOI：
10.1158/1055-9965.epi-08-0935
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kim S;Parks CG;DeRoo LA;Chen H;Taylor JA;Cawthon RM;Sandler DP
通讯作者：
Sandler DP
影响因子：
8.8
作者：
Schröder, CP;Wisman, GBA;de Vries, EGE
通讯作者：
de Vries, EGE
影响因子：
11.2
作者：
Pooley KA;Sandhu MS;Tyrer J;Shah M;Driver KE;Luben RN;Bingham SA;Ponder BA;Pharoah PD;Khaw KT;Easton DF;Dunning AM
通讯作者：
Dunning AM
影响因子：
6
作者：
Meeker, AK;Hicks, JL;Argani, P
通讯作者：
Argani, P