Inhibition of propofol anesthesia on functional connectivity between LFPs in PFC during rat working memory task.
Inhibition of propofol anesthesia on functional connectivity between LFPs in PFC during rat working memory task.
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异丙酚麻醉对大鼠工作记忆任务期间 PFC 中 LFP 之间功能连接的抑制
DOI：
10.1371/journal.pone.0083653
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Tian X
中科院分区：
文献类型：
--
作者：
Xu X;Tian Y;Li S;Li Y;Wang G;Tian X
工作记忆（Working memory， WM）是指对执行复杂认知任务所必需的信息的临时存储和操作。人们对异丙酚麻醉是否以及如何抑制WM功能越来越感兴趣。本研究的目的是基于多局部场电位（LFPs）和WM任务中行为的功能联系，探讨异丙酚麻醉可能的抑制机制。将成年SD大鼠随机分为3组：pro组（0.5 mg·kg−1·min−1,2 h）、pro组（0.9 mg·kg−1·min−1,2 h）和对照组。实验数据为异丙酚麻醉后24、48、72、96、120小时（第1天-第5天）SD大鼠y迷宫WM任务时，植入微电极阵列获得的16通道lfp，同时记录WM的行为结果。采用有向传递函数（DTF）方法直接分析lfp之间的联系。此外，通过DTF识别因果网络。选择聚类系数(C)、网络密度(D)和全局效率（egglobal）来定量描述功能连通性。结果表明：与对照组相比，pro组lfp功能连通性无显著差异（p < 0.05）；PRO组大鼠的连通性显著降低（24小时p<0.05, 48小时p<0.05）， 72、96、120小时无显著差异（p<0.05），与行为学结果一致。这些发现有助于从lfp之间的联系角度进一步了解麻醉对WM功能的抑制机制。
Working memory (WM) refers to the temporary storage and manipulation of information necessary for performance of complex cognitive tasks. There is a growing interest in whether and how propofol anesthesia inhibits WM function. The aim of this study is to investigate the possible inhibition mechanism of propofol anesthesia based on the functional connections of multi-local field potentials (LFPs) and behavior during WM tasks. Adult SD rats were randomly divided into 3 groups: pro group (0.5 mg·kg−1·min−1,2 h), PRO group (0.9 mg·kg−1·min−1, 2 h) and control group. The experimental data were 16-channel LFPs obtained at prefrontal cortex with implanted microelectrode array in SD rats during WM tasks in Y-maze at 24, 48, 72, 96, 120 hours (day 1-day 5) after propofol anesthesia, and the behavior results of WM were recoded at the same time. Directed transfer function (DTF) method was applied to analyze the connections among LFPs directly. Furthermore, the causal networks were identified by DTF. The clustering coefficient (C), network density (D) and global efficiency (Eglobal) were selected to describe the functional connectivity quantitatively. The results show that: comparing with the control group, the LFPs functional connectivity in pro group were no significantly difference (p>0.05); the connectivity in PRO group were significantly decreased (p<0.05 at 24 hours, p<0.05 at 48 hours), while no significant difference at 72, 96 and 120 hours for rats (p>0.05), which were consistent with the behavior results. These findings could lead to improved understanding the mechanism of inhibition of anesthesia on WM functions from the view of connections among LFPs.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1018985108
发表时间：
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影响因子：
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作者：
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