Evolution of cytochrome bc complexes: from membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates.
Evolution of cytochrome bc complexes: from membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates.
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DOI：
10.1016/j.bbabio.2013.07.006
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发表时间：
2013-11
影响因子：
4.3
通讯作者：
Mulkidjanian, Armen Y.
中科院分区：
文献类型：
--
作者：
Dibrova, Daria V.;Cherepanov, Dmitry A.;Galperin, Michael Y.;Skulachev, Vladimir P.;Mulkidjanian, Armen Y.
关键词：
本文回顾了细胞色素BC复合体从早期在原核生物谱系中的传播到线粒体细胞色素Bc1复合体(复合体III)的演变及其在细胞凋亡中的作用。系统发育分析结果表明，细菌细胞色素b6f型短细胞色素b型复合体是进化先于长细胞色素bc1型复合体的古老形式。b6f型和bc1型复合体的共同祖先可能类似于在螺杆菌科和一些Planctomycae中发现的b6f型复合体。细胞色素BC操纵子的侧向转移可以解释古生菌获得不同类型细菌细胞色素BC复合体的几种情况。大气的逐渐氧化可能是推动细胞色素BC复合体进一步分化和扩散的关键进化因素。一方面，氧可以作为一种非常有效的末端电子受体。另一方面，BC复合体成分的自动氧化导致活性氧物种(ROS)的产生，这需要B6F型和BC1型复合体以及其他功能耦合蛋白的不同适应。提出了一个详细的场景，即含有心磷脂的线粒体细胞色素Bc1复合体逐渐参与内在的凋亡途径，其中该复合体作为凋亡触发器的功能被视为一种加速消除具有不可修复的损伤的、产生ROS的线粒体的方法。
This review traces the evolution of the cytochrome bc complexes from their early spread among prokaryotic lineages and up to the mitochondrial cytochrome bc1 complex (complex III) and its role in apoptosis. The results of phylogenomic analysis suggest that the bacterial cytochrome b6f-type complexes with short cytochromes b were the ancient form that preceded in evolution the cytochrome bc1-type complexes with long cytochromes b. The common ancestor of the b6f-type and the bc1-type complexes probably resembled the b6f-type complexes found in Heliobacteriaceae and in some Planctomycetes. Lateral transfers of cytochrome bc operons could account for the several instances of acquisition of different types of bacterial cytochrome bc complexes by archaea. The gradual oxygenation of the atmosphere could be the key evolutionary factor that has driven further divergence and spread of the cytochrome bc complexes. On one hand, oxygen could be used as a very efficient terminal electron acceptor. On the other hand, auto-oxidation of the components of the bc complex results in the generation of reactive oxygen species (ROS), which necessitated diverse adaptations of the b6f-type and bc1-type complexes, as well as other, functionally coupled proteins. A detailed scenario of the gradual involvement of the cardiolipin-containing mitochondrial cytochrome bc1 complex into the intrinsic apoptotic pathway is proposed, where the functioning of the complex as an apoptotic trigger is viewed as a way to accelerate the elimination of the cells with irreparably damaged, ROS-producing mitochondria.
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影响因子：
6.5
作者：
Anisimova M;Gil M;Dufayard JF;Dessimoz C;Gascuel O
通讯作者：
Gascuel O
影响因子：
2.8
作者：
Agapova, L. S.;Chernyak, B. V.;Skulachev, V. P.
通讯作者：
Skulachev, V. P.
影响因子：
4.3
作者：
Bayir, H.;Fadeel, B.;Kagan, V. E.
通讯作者：
Kagan, V. E.
影响因子：
6.5
作者：
Anisimova, Maria;Gascuel, Olivier
通讯作者：
Gascuel, Olivier
DOI：
10.1098/rstb.2002.1184
发表时间：
2003-01-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Baymann, F;Lebrun, E;Nitschke, W
通讯作者：
Nitschke, W