Differential effect of weight loss with low-fat diet or high-fat diet restriction on inflammation in the liver and adipose tissue of mice with diet-induced obesity.
Differential effect of weight loss with low-fat diet or high-fat diet restriction on inflammation in the liver and adipose tissue of mice with diet-induced obesity.
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DOI：
10.1016/j.atherosclerosis.2011.07.025
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发表时间：
2011-11
期刊：
影响因子：
5.3
通讯作者：
Wu, Huaizhu
中科院分区：
文献类型：
--
作者：
Wang, Qun;Perrard, Xiaoyuan Dai;Perrard, Jerry L.;Mansoori, Amir;Raya, Joe L.;Hoogeveen, Ron;Smith, C. Wayne;Ballantyne, Christie M.;Wu, Huaizhu
我们研究了正常低脂饮食(ND)和限制高脂饮食(HFD)诱导的体重减轻对肥胖小鼠肝脏脂肪变性、肝脏和脂肪组织(AT)炎症以及单核细胞的影响。在HFD诱导的肥胖小鼠中，体重减轻的方法是从HFD转换为ND并随意保持ND，或者限制HFD的摄入量以匹配ND诱导的减肥小鼠的体重。饮食干预4周后，检测肝脏脂肪变性、肝脏和AT炎症及外周血CD11c+单核细胞数。在改变饮食后4周，体重比基线减少了23%。要达到同样的减重效果，就需要限制高脂饮食摄入的卡路里。限制ND或HFD的体重减轻可降低体脂质量和改善肝脏脂肪变性；ND诱导的体重减轻比HFD限制引起的体重减轻的影响更大。ND但不限制HFD的体重减轻通过趋化因子和CD11c表达来评估血CD11c+单核细胞正常化和减轻肝脏炎症。相反，与肥胖对照组相比，限制HFD的减肥显著降低了AT的趋化因子水平和CD11c+细胞，而且比ND诱导的减肥更倾向于减少AT趋化因子和CD11c+细胞。在饮食诱导的肥胖小鼠中，ND减肥在减轻肝脏炎症和脂肪变性方面优于ND，而HFD热量限制减肥对AT炎症有更大的改善作用。
We studied the effects of weight loss induced by either a low-fat normal diet (ND) or restriction of high-fat diet (HFD) on hepatic steatosis, inflammation in the liver and adipose tissue (AT), and blood monocytes of obese mice. In mice with HFD-induced obesity, weight loss was achieved by switching from HFD to ND and maintaining on ND ad libitum or by restricting HFD intake to match body weight of mice with ND-induced weight loss. After diet interventions for 4 weeks, hepatic steatosis, hepatic and AT inflammation, and blood CD11c+ monocytes were examined. At 4 weeks after switching diets, body weight was reduced by 23% from baseline. To achieve the same reduced body weight required restricting calorie intake from HFD. Weight loss with either ND or HFD restriction decreased body fat mass and ameliorated liver steatosis; both effects were greater with ND-induced weight loss than HFD restriction–induced weight loss. Weight loss with ND but not HFD restriction normalized blood CD11c+ monocytes and attenuated hepatic inflammation assessed by chemokine and CD11c expression. In contrast, weight loss with HFD restriction significantly reduced chemokine levels and CD11c+ cells in AT compared to obese controls, and tended to reduce AT chemokines and CD11c+ cells more than ND-induced weight loss. In mice with diet-induced obesity, weight loss with ND was superior in alleviating hepatic inflammation and steatosis, whereas weight loss with HFD calorie restriction provided greater amelioration of AT inflammation.
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影响因子：
24
作者：
Owan, Theophilus;Avelar, Erick;Litwin, Sheldon E.
通讯作者：
Litwin, Sheldon E.
影响因子：
8.2
作者：
Flachs, P;Mohamed-Ali, V;Kopecky, J
通讯作者：
Kopecky, J
影响因子：
6.5
作者：
Attie, AD;Krauss, RM;Ntambi, JM
通讯作者：
Ntambi, JM
DOI：
10.1056/nejmoa0804748
发表时间：
2009-02-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sacks FM;Bray GA;Carey VJ;Smith SR;Ryan DH;Anton SD;McManus K;Champagne CM;Bishop LM;Laranjo N;Leboff MS;Rood JC;de Jonge L;Greenway FL;Loria CM;Obarzanek E;Williamson DA
通讯作者：
Williamson DA
影响因子：
82.9
作者：
Berg, AH;Combs, TP;Scherer, PE
通讯作者：
Scherer, PE