Brain hyperconnectivity in children with autism and its links to social deficits.
Brain hyperconnectivity in children with autism and its links to social deficits.
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DOI：
10.1016/j.celrep.2013.10.001
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发表时间：
2013-11-14
期刊：
影响因子：
8.8
通讯作者：
Menon V
中科院分区：
文献类型：
--
作者：
Supekar K;Uddin LQ;Khouzam A;Phillips J;Gaillard WD;Kenworthy LE;Yerys BE;Vaidya CJ;Menon V
自闭症谱系障碍（ASD）是一种神经发育障碍，影响近1/88的儿童，被认为是由异常的大脑连接引起的。值得注意的是，还没有系统的尝试来描述ASD儿童的全脑连接。在这里，我们使用神经成像技术来显示与正常发育的儿童相比，ASD儿童的大脑中有更多的功能连接。ASD中的超连接性在全脑和子系统水平上被观察到，跨越长距离和短距离连接，并且与区域脑信号的更高水平的波动相关。大脑超连通性预测ASD的症状严重程度，因此具有更大功能连接的儿童表现出更严重的社会缺陷。我们在另外两个独立的队列中复制了这些发现，再次证明在早期，ASD的大脑在很大程度上是功能性超连接的，从而导致社会功能障碍。我们的发现为儿童自闭症的大脑机制提供了新的见解。
Autism spectrum disorder (ASD), a neurodevelopmental disorder affecting nearly 1 in 88 children, is thought to result from aberrant brain connectivity. Remarkably, there have been no systematic attempts to characterize whole-brain connectivity in children with ASD. Here, we use neuroimaging to show there are more instances of greater functional connectivity in the brains of children with ASD compared with typically developing children. Hyper-connectivity in ASD was observed at the whole-brain and subsystems level, across long- and short-range connections, and was associated with higher levels of fluctuations in regional brain signals. Brain hyper-connectivity predicted symptom severity in ASD such that children with greater functional connectivity exhibited more severe social deficits. We replicated these findings in two additional independent cohorts, demonstrating again that at earlier ages, the brain in ASD is largely functionally hyper-connected in ways that contribute to social dysfunction. Our findings provide novel insights into brain mechanisms underlying childhood autism.
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