Effects of a short course of estrogen on mineral metabolism in postmenopausal women.
Effects of a short course of estrogen on mineral metabolism in postmenopausal women.
复制标题
短期雌激素疗程对绝经后妇女矿物质代谢的影响。
DOI：
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发表时间：
1985
影响因子：
5.8
通讯作者：
Mallette Le
中科院分区：
文献类型：
--
作者：
J. Stock;J. Coderre;Mallette Le
先前的研究表明，雌激素的使用导致循环免疫反应性甲状旁腺激素（iPTH）的增加，这被认为是继发于抑制骨吸收导致的血清钙的轻微下降。使用三种不同的RIAs，我们测量了10名绝经后妇女在使用炔雌醇前后14天的血清iPTH。在2个针对PTH分子中间区域的敏感RIAs中，每个受试者的iPTH值下降或保持不变，两项检测中平均下降23% （P小于0.001）和28% （P小于0.005）。雌激素治疗后，尿总cAMP、尿磷酸盐排泄管最大值、血清iPTH均无变化。治疗后空腹尿钙、羟脯氨酸和血清钙、磷、白蛋白、碱性磷酸酶、骨钙素均下降，血清1,25-二羟维生素D均升高。在第二个队列中，5名妇女给予乙炔雌二醇8周，在2周时发现了类似的变化，但有升高血清iPTH的趋势，增加尿总cAMP排泄，降低尿磷酸盐排泄管最大值8周。雌激素治疗2周后，血清1,25-二羟基维生素D升高，血清骨钙素下降，尽管继续治疗，但没有进一步改变。这些结果表明，在血清iPTH或PTH活性的几种生物学指标未增加的情况下，2周雌激素治疗对矿物质代谢的多重影响。
Previous studies suggested that estrogen administration leads to an increase in circulating immunoreactive PTH (iPTH), thought to be secondary to a slight decrease in serum calcium resulting from inhibition of bone resorption. Using three different RIAs, we measured iPTH in serum from 10 postmenopausal women before and after 14 days of ethinyl estradiol administration. In 2 sensitive RIAs directed at the midregion of the PTH molecule, iPTH values fell or remained unchanged in each subject, with average decreases of 23% (P less than 0.001) and 28% (P less than 0.005) in the two assays. Total urinary cAMP, the tubular maximum for urinary phosphate excretion, and serum iPTH measured with the third RIA did not change after estrogen treatment. Fasting urinary calcium and hydroxyproline and serum calcium, phosphorus, albumin, alkaline phosphatase, and osteocalcin all decreased after treatment, and serum 1,25-dihydroxyvitamin D increased in each subject. In a second cohort of 5 women given ethinyl estradiol for 8 weeks, similar changes were found at 2 weeks, but there was a trend toward increasing serum iPTH, increasing total urinary cAMP excretion, and decreasing the tubular maximum for urinary phosphate excretion by 8 weeks. The increase in serum 1,25-dihydroxyvitamin D and the decrease in serum osteocalcin were again found after 2 weeks of estrogen and did not change further despite continued treatment. These results indicate multiple effects of a 2-week course of estrogen treatment on mineral metabolism in the absence of an increase in serum iPTH or several biological indices of PTH activity.
DOI：
10.1016/s0021-9258(18)42960-2
发表时间：
1981-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
P. Price;M. Williamson;J. W. Lothringer
通讯作者：
P. Price;M. Williamson;J. W. Lothringer
影响因子：
5.8
作者：
GALLAGHER, JC;RIGGS, BL;DELUCA, HF
通讯作者：
DELUCA, HF
影响因子：
15.9
作者：
PRICE, PA;PARTHEMORE, JG;NISHIMOTO, SK
通讯作者：
NISHIMOTO, SK