Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death.
Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death.
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DOI:
10.18632/oncotarget.9906
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发表时间:
2016-07-05
期刊:
影响因子:
--
通讯作者:
Liang JA
中科院分区:
文献类型:
--
作者:
Huang WY;Li CH;Lin CL;Liang JA
Clinical studies have obtained inconsistent results of statin use on cancer outcomes. This study investigated the association between statin use and lung cancer mortality. The use of statin decreased mortality (hazard ratio = 0.91; 95% confidence interval: 0.86–0.96; P < .01). The patients with a high cumulative defined daily dose of statin use before lung cancer diagnosis exhibited a low risk of mortality. We conducted a population-based case-control study of patients with dyslipidemia. Among them, 6270 had used statins for at least 3 months before lung cancer diagnosis, and 6270 had never used statins. We found that statin use can reduce lung cancer mortality. A further prospective study is necessary to confirm these findings.
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