Intramuscular cobinamide as an antidote to methyl mercaptan poisoning.
Intramuscular cobinamide as an antidote to methyl mercaptan poisoning.
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DOI：
10.1080/08958378.2020.1866123
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发表时间：
2021-01
影响因子：
2.1
通讯作者：
Bebarta VS
中科院分区：
文献类型：
--
作者：
Hendry-Hofer TB;Ng PC;McGrath AM;Soules K;Mukai DS;Chan A;Maddry JK;White CW;Lee J;Mahon SB;Brenner M;Boss GR;Bebarta VS
甲基苯丙胺自然存在于环境中，并存在于各种职业环境中，包括石油，造纸，塑料和农药行业。它是一种有毒气体，因接触甲硫醇而死亡的事件已经发生。国土安全部认为它是一种高威胁化学剂，可能被恐怖分子使用。不幸的是，没有具体的治疗方法存在甲基苯丙胺中毒。我们在12头猪中进行了一项随机试验，比较了急性吸入甲基氯仿后未治疗与肌肉注射维生素B12类似物可宾酰胺（2.0 ml，12.5 mg/kg）。在基线和治疗时，对照组和考比胺治疗组的生理和实验室参数相似。所有6只考比胺治疗动物均存活，而6只对照动物中仅1只存活（17%存活）（p=0.0043）。给药后3.8 ±1.1 min（平均值± SD），接受钴氨酰胺给药的动物恢复正常呼吸模式，而对照组中除1只动物外，所有动物均出现间歇性喘息，从未恢复正常呼吸模式。血压和动脉血氧饱和度在考比那胺治疗后15分钟内恢复到基线值。对照组动物的血浆乳酸盐浓度逐渐升高，直至死亡（10.93±6.02 mmol [平均值±SD]），而考比那胺给药组动物的血浆乳酸盐浓度在实验结束时降至基线水平（3.79±2.93 mmol [平均值±SD]）。我们的结论是，肌内注射可宾胺改善急性大剂量甲基苯丙胺中毒的大型动物模型的生存率和临床结局。
Methyl mercaptan occurs naturally in the environment, and is found in a variety of occupational settings, including the oil, paper, plastics, and pesticides industries. It is a toxic gas, and deaths from methyl mercaptan exposure have occurred. The Department of Homeland Security considers it a high threat chemical agent that could be used by terrorists. Unfortunately, no specific treatment exists for methyl mercaptan poisoning. We conducted a randomized trial in 12 swine comparing no treatment to intramuscular injection of the vitamin B12 analog cobinamide (2.0 ml, 12.5 mg/kg) following acute inhalation of methyl mercaptan gas. Physiological and laboratory parameters were similar in the control and cobinamide-treated groups at baseline and at the time of treatment. All six cobinamide-treated animals survived, whereas only one of six control animals lived (17% survival) (p=0.0043). The cobinamide-treated animals returned to a normal breathing pattern by 3.8 ±1.1 min after treatment (mean ± SD), while all but one animal in the control group had intermittent gasping, never regaining a normal breathing pattern. Blood pressure and arterial oxygen saturation returned to baseline values within 15 minutes of cobinamide-treatment. Plasma lactate concentration increased progressively until death (10.93±6.02 mmol [mean±SD]) in control animals, and decreased towards baseline (3.79±2.93 mmol [mean±SD]) by the end of the experiment in cobinamide-treated animals. We conclude that intramuscular administration of cobinamide improves survival and clinical outcomes in a large animal model of acute, high dose methyl mercaptan poisoning.
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影响因子：
2.9
作者：
Lee, Jangwoen;Mahon, Sari B.;Brenner, Matthew
通讯作者：
Brenner, Matthew
DOI：
10.1007/s004200050195
发表时间：
1997-08-01
影响因子：
3
作者：
Kauppinen, T;Teschke, K;Boffetta, P
通讯作者：
Boffetta, P
影响因子：
7.3
作者：
Chan, Adriano;Jiang, Jingjing;Boss, Gerry R.
通讯作者：
Boss, Gerry R.
影响因子：
6.3
作者：
KLINGBERG, J;BEVIZ, A;TENHUNEN, R
通讯作者：
TENHUNEN, R
影响因子：
3.3
作者：
Ng, Patrick C.;Hendry-Hofer, Tara B.;Bebarta, Vikhyat S.
通讯作者：
Bebarta, Vikhyat S.