GSK-3 as potential target for therapeutic intervention in cancer.
GSK-3 as potential target for therapeutic intervention in cancer.
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DOI：
10.18632/oncotarget.2037
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发表时间：
2014-05-30
期刊：
影响因子：
--
通讯作者：
Cervello M
中科院分区：
文献类型：
--
作者：
McCubrey JA;Steelman LS;Bertrand FE;Davis NM;Sokolosky M;Abrams SL;Montalto G;D'Assoro AB;Libra M;Nicoletti F;Maestro R;Basecke J;Rakus D;Gizak A;Demidenko ZN;Cocco L;Martelli AM;Cervello M
丝氨酸/苏氨酸激酶糖原合成酶-3(GSK-3)在糖原合成的调节中被初步鉴定和研究。GSK-3在广泛的细胞过程中发挥作用。GSK-3的异常活性与许多人类疾病有关，包括：躁郁症、阿尔茨海默病、帕金森氏病、癌症、非胰岛素依赖型糖尿病(NIDDM)等。在某些情况下，Akt和其他激酶通过磷酸化抑制GSK-3的活性与癌症的进展有关。在这些情况下，GSK-3具有肿瘤抑制功能。在其他情况下，GSK-3通过稳定β-连环蛋白复合体的成分与肿瘤进展有关。在这些情况下，GSK-3具有致癌特性。虽然已经开发了许多GSK-3的抑制剂，但由于GSK-3在癌症发展中的模糊作用，它们的使用仍然存在争议。在这篇综述中，我们将集中讨论GSK-3在各种人类癌症中扮演的不同角色，特别是在实体瘤中。最近，GSK-3还与各种细胞类型的癌症干细胞的产生有关。我们还将讨论该关键激酶如何与多个信号通路相互作用，如：PI3K/PTEN/Akt/mTORC1、Ras/Raf/MEK/ERK、Wnt/β-catenin、Hedgehog、Notch等。
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular processes. Aberrant activity of GSK-3 has been implicated in many human pathologies including: bipolar depression, Alzheimer's disease, Parkinson's disease, cancer, non-insulin-dependent diabetes mellitus (NIDDM) and others. In some cases, suppression of GSK-3 activity by phosphorylation by Akt and other kinases has been associated with cancer progression. In these cases, GSK-3 has tumor suppressor functions. In other cases, GSK-3 has been associated with tumor progression by stabilizing components of the beta-catenin complex. In these situations, GSK-3 has oncogenic properties. While many inhibitors to GSK-3 have been developed, their use remains controversial because of the ambiguous role of GSK-3 in cancer development. In this review, we will focus on the diverse roles that GSK-3 plays in various human cancers, in particular in solid tumors. Recently, GSK-3 has also been implicated in the generation of cancer stem cells in various cell types. We will also discuss how this pivotal kinase interacts with multiple signaling pathways such as: PI3K/PTEN/Akt/mTORC1, Ras/Raf/MEK/ERK, Wnt/beta-catenin, Hedgehog, Notch and others.
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影响因子：
11.1
作者：
Bernardi, Rosa;Papa, Antonella;Egia, Ainara;Coltella, Nadia;Teruya-Feldstein, Julie;Signoretti, Sabina;Pandolfi, Pier Paolo
通讯作者：
Pandolfi, Pier Paolo
影响因子：
4.8
作者：
Bakre, Manjiri Manohar;Hoi, Aina;Stanton, Lawrence W.
通讯作者：
Stanton, Lawrence W.
影响因子：
3.7
作者：
Aguilar-Morante D;Morales-Garcia JA;Sanz-SanCristobal M;Garcia-Cabezas MA;Santos A;Perez-Castillo A
通讯作者：
Perez-Castillo A
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
影响因子：
6.4
作者：
BARTKOVA, J;LUKAS, J;BARTEK, J
通讯作者：
BARTEK, J