Oligodendroglial microtubular masses: An abnormality observed in some human neurodegenerative diseases
Oligodendroglial microtubular masses: An abnormality observed in some human neurodegenerative diseases
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少突胶质细胞微管肿块：在一些人类神经退行性疾病中观察到的异常
DOI：
10.1016/0304-3940(90)90028-8
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发表时间：
1990
影响因子：
2.5
通讯作者：
P. Mcgeer
中科院分区：
文献类型：
--
作者：
T. Yamada;P. Mcgeer
Oligodendroglial microtubular masses (OMMs) were identified immunohistochemically in brain tissue from patients with such degenerative disorders as Alzheimer disease, Pick's disease and argyrophilic grain dementia. The OMMs were identified by Alz-50 and antibodies to Tau-2, paired helical filaments and ubiquitin. They occurred preferentially in white matter. They were composed of fibers 25 nm in diameter and were localized to the cytoplasma of oligodendroglia and processes of oligodendroglia ensheathing damaged axons. They sometimes occurred in oligodendroglia also stained by antibody to the complement protein C4d. These data suggest that OMMs represent abnormal microtubular accumulations in oligodendroglia, possibly as a reaction to axonal damage.
唐氏综合症和阿尔茨海默病中发育调节抗原的重新表达。
DOI：
10.1073/pnas.85.16.6202
发表时间：
1988
影响因子：
11.1
作者：
Wolozin,B;Scicutella,A;Davies,P
通讯作者：
Davies,P
正常人脑中的泛素免疫反应结构。
DOI：
--
发表时间：
1990
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Dickson,DW;Wertkin,A;Kress,Y;Ksiezak-Reding,H;Yen,SH
通讯作者：
Yen,SH