Effects of xylitol on metabolic parameters and visceral fat accumulation.
Effects of xylitol on metabolic parameters and visceral fat accumulation.
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DOI：
10.3164/jcbn.10-111
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发表时间：
2011-07
影响因子：
2.4
通讯作者：
Takeda E
中科院分区：
文献类型：
--
作者：
Amo K;Arai H;Uebanso T;Fukaya M;Koganei M;Sasaki H;Yamamoto H;Taketani Y;Takeda E
木糖醇广泛用作食品和药物中的甜味剂。摄入木糖醇会导致血糖小幅升高，通常用作糖尿病患者高能量补充剂的替代品。在之前的研究中，木糖醇代谢物5-磷酸木酮糖被证明可以激活碳水化合物反应元件结合蛋白，并在体外促进脂肪生成酶基因转录；然而，木糖醇在体内的作用尚不清楚。在这里，我们研究了膳食木糖醇对高脂饮食大鼠脂质代谢和内脏脂肪积累的影响。 Sprague-Dawley 大鼠喂食含有 0 g（对照）、1.0 g/100 kcal (X1) 或 2.0 g/100 kcal (X2) 木糖醇的高脂肪饮食。 8周喂养期后，木糖醇喂养大鼠的内脏脂肪量以及血浆胰岛素和脂质浓度显着低于高脂饮食大鼠。与高脂饮食大鼠相比，木糖醇喂养大鼠肝脏中 ChREBP 和脂肪生成酶的基因表达水平较高，而甾醇调节元件结合蛋白 1c 的表达较低，脂肪酸氧化相关基因显着较高。总之，摄入木糖醇可能有益于预防饮食引起的肥胖大鼠的肥胖和代谢异常。
Xylitol is widely used as a sweetener in foods and medications. Xylitol ingestion causes a small blood glucose rise, and it is commonly used as an alternative to high-energy supplements in diabetics. In previous studies, a xylitol metabolite, xylulose-5-phosphate, was shown to activate carbohydrate response element binding protein, and to promote lipogenic enzyme gene transcription in vitro; however, the effects of xylitol in vivo are not understood. Here we investigated the effects of dietary xylitol on lipid metabolism and visceral fat accumulation in rats fed a high-fat diet. Sprague-Dawley rats were fed a high-fat diet containing 0 g (control), 1.0 g/100 kcal (X1) or 2.0 g/100 kcal (X2) of xylitol. After the 8-week feeding period, visceral fat mass and plasma insulin and lipid concentrations were significantly lower in xylitol-fed rats than those in high-fat diet rats. Gene expression levels of ChREBP and lipogenic enzymes were higher, whereas the expression of sterol regulatory-element binding protein 1c was lower and fatty acid oxidation-related genes were significantly higher in the liver of xylitol-fed rats as compared with high-fat diet rats. In conclusion, intake of xylitol may be beneficial in preventing the development of obesity and metabolic abnormalities in rats with diet-induced obesity.
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影响因子：
7.1
作者：
Brand-Miller, JC;Holt, SHA;McMillan, J
通讯作者：
McMillan, J
DOI：
10.1073/pnas.0401516101
发表时间：
2004-05-11
影响因子：
11.1
作者：
Iizuka, K;Bruick, RK;Uyeda, K
通讯作者：
Uyeda, K
影响因子：
8.2
作者：
Hammarstedt, A;Sopasakis, VR;Smith, U
通讯作者：
Smith, U
DOI：
10.1073/pnas.96.22.12737
发表时间：
1999-10-26
影响因子：
11.1
作者：
Foretz, M;Guichard, C;Foufelle, F
通讯作者：
Foufelle, F
代谢综合征的小鼠模型；内脏脂肪组织的增加先于高脂饮食喂养的雄性KK/TA小鼠的脂肪肝和胰岛素抵抗的发展。
影响因子：
2.4
作者：
Akagiri, Satomi;Naito, Yuji;Ichikawa, Hiroshi;Mizushima, Katsura;Takagi, Tomohisa;Handa, Osamu;Kokura, Satoshi;Yoshikawa, Toshikazu
通讯作者：
Yoshikawa, Toshikazu