Response to stress in biological disorders: Implications of stress granule assembly and function.
Response to stress in biological disorders: Implications of stress granule assembly and function.
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生物疾病中对应激的反应：应激颗粒组装和功能的影响
DOI：
10.1111/cpr.13086
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发表时间：
2021-08
影响因子：
8.5
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Wang L;Yang W;Li B;Yuan S;Wang F
为了生物的生存，细胞对环境压力的适应和反应是必不可少的。应激颗粒(SGS)是真核生物细胞质中动态形成的一种浓缩的无膜细胞器，用于应对各种细胞内外的应激因素，具有液-液相分离的特点。它们由多种成分组成，包括翻译停滞的mRNAs、翻译起始因子、RNA结合蛋白和非RNA结合蛋白。SG的形成是由应激刺激、病毒感染和信号转导触发的，而SGS的异常组装可能与组织退行性疾病有关。近年来，越来越多的证据表明，高温、氧化应激和渗透应激对细胞的SG反应机制有重要影响。本文综述了影响SGS组装的因素，介绍了SGS对生殖细胞发育和其他生物学过程的影响。我们特别强调最近报道的RNA修饰在SG应激反应中的重要性。同时，我们还回顾了目前关于SGS在雄性生殖细胞中作用的所有观点，特别关注SG组装的动力学。雄性生殖细胞热应激示意图。热应激通过磷酸化eIF2RNA，募集α结合蛋白(DAZL、BULE、RACK、MAGE-B2)，最终保护正常生精细胞免于生殖细胞凋亡，从而诱导应激颗粒(SG)的形成。EIF2α(真核细胞启动因子-2α)、MAPK(丝裂原活化蛋白激酶)、DAZL(无精子样缺失)、BOULE(DAZ基因家族的创始成员)、RAK(活化蛋白激酶C受体)、MAGE-B2(睾丸特异蛋白)
It is indispensable for cells to adapt and respond to environmental stresses, in order for organisms to survive. Stress granules (SGs) are condensed membrane‐less organelles dynamically formed in the cytoplasm of eukaryotes cells to cope with diverse intracellular or extracellular stress factors, with features of liquid‐liquid phase separation. They are composed of multiple constituents, including translationally stalled mRNAs, translation initiation factors, RNA‐binding proteins and also non‐RNA‐binding proteins. SG formation is triggered by stress stimuli, viral infection and signal transduction, while aberrant assembly of SGs may contribute to tissue degenerative diseases. Recently, a growing body of evidence has emerged on SG response mechanisms for cells facing high temperatures, oxidative stress and osmotic stress. In this review, we aim to summarize factors affecting SGs assembly, present the impact of SGs on germ cell development and other biological processes. We particularly emphasize the significance of recently reported RNA modifications in SG stress responses. In parallel, we also review all current perspectives on the roles of SGs in male germ cells, with a particular focus on the dynamics of SG assembly. Schematic illustration for heat stress in male germ cells. Heat stress induces stress granule (SG) formation by phosphorylating eIF2α, recruiting RNA binding protein (DAZL, BOULE, RACK, MAGE‐B2) and ultimately protecting normal spermatogenesis from germ cell apoptosis. eIF2α (eukaryotic initiation factor‐2alpha), MAPK (mitogen‐activated protein kinases), DAZL (deleted in azoospermia‐like), BOULE (a founding member of the DAZ gene family), RACK (receptor for activated protein kinase C), MAGE‐B2 (testis‐specific protein)
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影响因子：
16
作者：
Eisinger-Mathason, T. S. Karin;Andrade, Josefa;Groehler, Angela L.;Clark, David E.;Muratore-Schroeder, Tara L.;Pasic, Lejla;Smith, Jeffrey A.;Shabanowitz, Jeffrey;Hunt, Donald F.;Macara, Ian G.;Lannigan, Deborah A.
通讯作者：
Lannigan, Deborah A.
影响因子：
7.8
作者：
Buchan, J. Ross;Muhlrad, Denise;Parker, Roy
通讯作者：
Parker, Roy
影响因子：
4.4
作者：
Anders M;Chelysheva I;Goebel I;Trenkner T;Zhou J;Mao Y;Verzini S;Qian SB;Ignatova Z
通讯作者：
Ignatova Z
影响因子：
5.5
作者：
Alriquet M;Calloni G;Martínez-Limón A;Delli Ponti R;Hanspach G;Hengesbach M;Tartaglia GG;Vabulas RM
通讯作者：
Vabulas RM
影响因子：
10.5
作者：
Damgaard, Christian Kroun;Lykke-Andersen, Jens
通讯作者：
Lykke-Andersen, Jens