Induced pluripotent stem cell technology: a decade of progress.
Induced pluripotent stem cell technology: a decade of progress.
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DOI：
10.1038/nrd.2016.245
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Yamanaka S
中科院分区：
文献类型：
--
作者：
Shi Y;Inoue H;Wu JC;Yamanaka S
自十年前诱导多能干细胞（iPSC）技术出现以来，干细胞生物学和再生医学取得了巨大进展。人类 iPSC 已广泛用于疾病建模、药物发现和细胞疗法开发。新的病理机制已被阐明，源自 iPSC 筛选的新药正在研发中，并且首次使用人类 iPSC 衍生产品的临床试验已经启动。特别是，人类 iPSC 技术与基因编辑和三维类器官的最新发展相结合，使得基于 iPSC 的平台在其各个应用领域（包括精准医学）变得更加强大。在本概述中，我们将根据该领域剩余的挑战和新出现的机遇，讨论与药物发现和再生医学特别相关的 iPSC 技术应用的进展。
Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modeling, drug discovery, and cell therapy development. Novel pathological mechanisms have been elucidated, new drugs originating from iPSC screens are in the pipeline, and the first clinical trial using human iPSC-derived products has been initiated. In particular, the combination of human iPSC technology with recent developments in gene editing and three-dimensional organoids makes iPSC-based platforms even more powerful in each area of their application, including precision medicine. In this overview, we will discuss the progress in applications of iPSC technology that are particularly relevant to drug discovery and regenerative medicine, in light of the remaining challenges and the emerging opportunities in the field.
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DOI：
10.1016/j.mcn.2013.07.007
发表时间：
2013-09
期刊：
Molecular and cellular neurosciences
影响因子：
--
作者：
Burkhardt MF;Martinez FJ;Wright S;Ramos C;Volfson D;Mason M;Garnes J;Dang V;Lievers J;Shoukat-Mumtaz U;Martinez R;Gai H;Blake R;Vaisberg E;Grskovic M;Johnson C;Irion S;Bright J;Cooper B;Nguyen L;Griswold-Prenner I;Javaherian A
通讯作者：
Javaherian A
影响因子：
11.2
作者：
Cao F;Li Z;Lee A;Liu Z;Chen K;Wang H;Cai W;Chen X;Wu JC
通讯作者：
Wu JC
影响因子：
8.8
作者：
Chang, Chia-Wei;Lai, Yi-Shin;Townes, Tim M.
通讯作者：
Townes, Tim M.
影响因子：
17.1
作者：
Cooper O;Seo H;Andrabi S;Guardia-Laguarta C;Graziotto J;Sundberg M;McLean JR;Carrillo-Reid L;Xie Z;Osborn T;Hargus G;Deleidi M;Lawson T;Bogetofte H;Perez-Torres E;Clark L;Moskowitz C;Mazzulli J;Chen L;Volpicelli-Daley L;Romero N;Jiang H;Uitti RJ;Huang Z;Opala G;Scarffe LA;Dawson VL;Klein C;Feng J;Ross OA;Trojanowski JQ;Lee VM;Marder K;Surmeier DJ;Wszolek ZK;Przedborski S;Krainc D;Dawson TM;Isacson O
通讯作者：
Isacson O
影响因子：
46.9
作者：
Cho, Seung Woo;Kim, Sojung;Kim, Jin-Soo
通讯作者：
Kim, Jin-Soo