MR-guided stereotactic navigation.

MR-guided stereotactic navigation.
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DOI:
10.1016/j.jneumeth.2011.11.031
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发表时间:
2012-03-15
影响因子:
3
通讯作者:
Tsao DY
Tsao DY
中科院分区:
医学4区
文献类型:
--
作者:
Ohayon S;Tsao DY

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功能性磁共振成像可以精确定位专门用于不同感知和更高认知功能的大脑区域。然而,针对这些深部脑结构进行电生理学仍然是一项具有挑战性的任务。在这里,我们提出了一个新的框架,MRI立体定向登记和腔室放置精确的电极引导记录网站定义在MRI空间。所提出的“浮动框架”方法可以在不使用耳杆的情况下使用,大大减少了标准立体定向手术中常见的疼痛和不适。开发了定制的术前规划软件,以自动解决配准问题,并报告定位立体定向操纵器所需的一组参数,以沿着任意非垂直轨迹到达记录部位。此外,该软件可以自动识别血管,并帮助找到安全的目标轨迹。我们的方法通过靶向猕猴和大鼠的不同区域进行了验证。我们希望我们的方法将有助于记录在新的大脑区域,并提供一个有价值的工具,电生理学家。
Functional magnetic resonance imaging allows precise localization of brain regions specialized for different perceptual and higher cognitive functions. However, targeting these deep brain structures for electrophysiology still remains a challenging task. Here, we propose a novel framework for MRI-stereotactic registration and chamber placement for precise electrode guidance to recording sites defined in MRI space. The proposed “floating frame” approach can be used without usage of ear bars, greatly reducing pain and discomfort common in standard stereotactic surgeries. Custom pre-surgery planning software was developed to automatically solve the registration problem and report the set of parameters needed to position a stereotactic manipulator to reach a recording site along arbitrary, non-vertical trajectories. Furthermore, the software can automatically identify blood vessels and assist in finding safe trajectories to targets. Our approach was validated by targeting different regions in macaque monkeys and rats. We expect that our method will facilitate recording in new brain areas and provide a valuable tool for electrophysiologists.
一种新的 MRI 方法可将微电极准确植入恒河猴(Macaca mulatta)的大脑深部结构
DOI: 10.1016/j.jneumeth.2010.07.039
发表时间: 2010-11-30
影响因子: 3
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作者:
SERENO, MI;DALE, AM;TOOTELL, RBH
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