Cognition-induced modulation of serotonin in the orbitofrontal cortex: A controlled cross-over PET study of a delayed match-to-sample task using the 5-HT2a receptor antagonist [18F]altanserin
Cognition-induced modulation of serotonin in the orbitofrontal cortex: A controlled cross-over PET study of a delayed match-to-sample task using the 5-HT2a receptor antagonist [18F]altanserin
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眶额皮质中认知诱导的血清素调节：使用 5-HT2a 受体拮抗剂 [18F]阿坦色林进行延迟匹配样本任务的受控交叉 PET 研究
DOI：
10.1016/j.neuroimage.2011.06.009
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发表时间：
2011
期刊：
影响因子：
5.7
通讯作者：
R. Grandt
中科院分区：
文献类型：
--
作者：
H. Hautzel;H. Müller;H. Herzog;R. Grandt
行为和细胞研究表明，5-羟色胺与5-HT 2a受体（5-HT 2aR）相互作用参与支持工作记忆（WM）的认知过程。然而，5-HT受体神经影像学研究直接相关WM诱导的神经元激活伴随5-HT受体作为5-羟色胺释放的功能措施的可用性的变化是缺乏的。这项对照交叉PET研究旨在鉴定WM诱导的5-HT 2aR拮抗剂[18 F]阿坦色林结合电位（BPnd）变化的脑区。10名年轻男性进行了延迟匹配到样本的任务，使用照片的脸和控制任务。通过应用Ichise的非侵入性图计算两种条件的BP_（nd）。使用SPM工具箱统计非参数映射（SnPM 3）进行统计，特别适合以探索性方式分析全脑PET数据。在WM过程中，[18 F]阿坦色林在眶额皮质（OFC）中的BPnd高于对照组，表明OFC中[18 F]阿坦色林/5-HT 2aR相互作用增加，而WM过程中BPnd未降低。这些发现可能表明WM激发下[18 F]阿坦色林BPnd增加，因此5-HT 2a R可用性增加反映了局部OFC 5-羟色胺的减少。由于眶额皮层在决策过程中起着重要作用，并支持与WM的中央执行功能相关的认知过程，因此它可能通过5-HT 2aR被肾上腺素能系统调节，以支持和优化基本的认知功能。
Behavioral and cellular studies indicate that serotonin interacting with the 5-HT2a receptor (5-HT2aR) is involved in cognitive processes supporting working memory (WM). However, 5-HT receptor neuroimaging studies directly relating WM-induced neuronal activations to concomitant changes in the availability of 5-HT receptors as a functional measure for serotonin release are lacking. This controlled cross-over PET study aimed to identify brain regions with WM-induced changes in the binding potential (BPnd) of the 5-HT2aR antagonist [18F]altanserin. Ten young males underwent a delayed match-to-sample task using photographs of faces and a control task. The BPnds for both conditions were calculated by applying Ichise's noninvasive plot. Statistics were performed with the SPM toolbox statistical nonparametric mapping (SnPM3) particularly suited for analyzing whole-brain PET data in an exploratory way. A higher BPndfor [18F]altanserin during WM versus control was found in the orbitofrontal cortex (OFC) pointing towards an increased [18F]altanserin/5-HT2aR interaction in OFC while BPnddecreases during WM were not found. Furthermore, no BPndchanges in regions known from functional neuroimaging studies to be more specifically involved in WM were identified. These findings may suggest that the increased [18F]altanserin BPndunder WM challenge and hence the increased availability of 5-HT2aR reflects a decrease in local OFC serotonin. As the OFC plays a prominent role in decision-making and supports cognitive processes related to the central executive functions of WM it might be modulated by the serotoninergic system via the 5-HT2aR in order to support and optimize basic cognitive functions.
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影响因子：
4
作者：
L. Luttrell;R. Lefkowitz
通讯作者：
L. Luttrell;R. Lefkowitz
影响因子：
4.2
作者：
Long, Arwen B.;Kuhn, Cynthia M.;Platt, Michael L.
通讯作者：
Platt, Michael L.
影响因子：
3.7
作者：
Luciana, M;Collins, PF;Depue, RA
通讯作者：
Depue, RA
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影响因子：
3.6
作者：
Leonhardt,S;Gorospe,E;Hoffman,BJ;Teitler,M
通讯作者：
Teitler,M