Cross-reactive myelin antibody induces renal pathology.
Cross-reactive myelin antibody induces renal pathology.
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DOI：
10.1080/08916930802128680
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发表时间：
2008-11
期刊：
影响因子：
3.5
通讯作者：
Fujinami RS
中科院分区：
文献类型：
--
作者：
Peterson LK;Masaki T;Wheelwright SR;Tsunoda I;Fujinami RS
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune model for multiple sclerosis (MS). Previously, we reported renal immunoglobulin (Ig) deposition in mice with myelin oligodendrocyte glycoprotein (MOG92-106) induced progressive-EAE and naïve mice injected with MOG92-106 hybridoma cells producing antibody that cross-reacts with various autoantigens including double-stranded DNA. To assess whether MOG92-106 antibodies actually induce kidney changes, the extent of renal Ig deposition and changes in glomerular histology and filtration were investigated. Mice with progressive-EAE exhibited Ig deposition, glomerular hypercellularity and proteinuria indicating kidney dysfunction. MOG92-106 hybridoma cell injected mice also had Ig in the kidneys and proteinuria. Therefore, sensitization with MOG92-106 and transfer of MOG92-106 antibodies can induce both central nervous system and renal pathology. The renal involvement reported in MS is believed to occur as a side effect of nephrotoxic drugs or neurogenic bladder. Our results demonstrate that an autoimmune response against myelin could induce pathologic changes in the kidney and may help explain renal changes reported in patients with progressive MS.
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影响因子：
15.3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/b978-044452763-9/50007-x
发表时间：
2007-01-01
期刊：
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影响因子：
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作者：
Peterson, Lisa K.;Fujinami, Robert S.
通讯作者：
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DOI：
10.1016/0169-328x(95)00190-4
发表时间：
1995-12-28
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
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作者：
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通讯作者：
Rodriguez, M
影响因子：
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作者：
Calabresi, PA;Austin, H;McFarland, HF
通讯作者：
McFarland, HF