The precursors of CD8(+) tissue resident memory T cells: from lymphoid organs to infected tissues.
The precursors of CD8(+) tissue resident memory T cells: from lymphoid organs to infected tissues.
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DOI：
10.1038/s41577-021-00590-3
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Schumacher TN
中科院分区：
文献类型：
--
作者：
Kok L;Masopust D;Schumacher TN
CD8+组织驻留记忆T细胞（TRM细胞）对于针对病原体和恶性肿瘤的免疫防御是必不可少的，并且导致TRM细胞形成的分子过程因此具有实质性的生物医学意义。先前的工作已经证明，发炎组织微环境中存在的信号可以促进记忆前体细胞分化为成熟的TRM细胞，因此长期以来一直认为TRM细胞形成遵循“局部分化”模型，其中TRM细胞谱系决定仅在组织内做出。然而，越来越多的工作为“系统性趋异”模型提供了证据，在该模型中，循环T细胞已经被预处理以优先产生TRM细胞谱系，导致在淋巴区室内产生TRM细胞平衡的T细胞池。在这里，我们回顾了支持这种循环TRM祖细胞群体存在的新证据，讨论了目前对其形成的见解，并强调了该领域的开放问题。CD8+组织驻留记忆T细胞（TRM细胞）对于防御病原体和恶性肿瘤是必不可少的。先前的工作表明，这些细胞在发炎组织内形成，但有新的证据表明，TRM细胞前体库存在于循环中。这篇综述探讨了淋巴细胞内决定TRM细胞形成的谱系决定的过程和信号。
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to TRM cell formation are therefore of substantial biomedical interest. Prior work has demonstrated that signals present in the inflamed tissue micro-environment can promote the differentiation of memory precursor cells into mature TRM cells, and it was therefore long assumed that TRM cell formation adheres to a ‘local divergence’ model, in which TRM cell lineage decisions are exclusively made within the tissue. However, a growing body of work provides evidence for a ‘systemic divergence’ model, in which circulating T cells already become preconditioned to preferentially give rise to the TRM cell lineage, resulting in the generation of a pool of TRM cell-poised T cells within the lymphoid compartment. Here, we review the emerging evidence that supports the existence of such a population of circulating TRM cell progenitors, discuss current insights into their formation and highlight open questions in the field. CD8+ tissue resident memory T cells (TRM cells) are essential for defence against pathogens and malignancies. Prior work had indicated that these cells form within inflamed tissue, but there is emerging evidence that a pool of TRM cell precursors exists within the circulation. This Review examines the processes and signals within the lymphoid compartment that determine lineage decisions towards the formation of TRM cells.
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DOI：
10.1084/jem.20011502
发表时间：
2002-01-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell DJ;Butcher EC
通讯作者：
Butcher EC
影响因子：
82.9
作者：
Adachi T;Kobayashi T;Sugihara E;Yamada T;Ikuta K;Pittaluga S;Saya H;Amagai M;Nagao K
通讯作者：
Nagao K
影响因子：
15.9
作者：
Boddupalli, Chandra Sekhar;Nair, Shiny;Dhodapkar, Madhav V.
通讯作者：
Dhodapkar, Madhav V.
影响因子：
32.4
作者：
Delacher, Michael;Imbusch, Charles D.;Feuerer, Markus
通讯作者：
Feuerer, Markus
影响因子：
32.4
作者：
Borges da Silva H;Peng C;Wang H;Wanhainen KM;Ma C;Lopez S;Khoruts A;Zhang N;Jameson SC
通讯作者：
Jameson SC