Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues.
Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues.
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DOI：
10.1084/jem.20011502
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发表时间：
2002-01-07
期刊：
影响因子：
--
通讯作者：
Butcher EC
中科院分区：
文献类型：
--
作者：
Campbell DJ;Butcher EC
效应T细胞和记忆T细胞可以根据其通过外周组织（如发炎的皮肤和肠固有层）的能力进行细分，这是一种由“组织特异性”粘附和化学引诱物受体表达控制的特性。然而，鲜为人知的是，这些选择性归巢T细胞亚群的发展，目前还不清楚是否在皮肤与肠淋巴器官的激活直接导致效应/记忆T细胞，差异表达的粘附和趋化受体靶向他们相应的nonlymphoid网站。我们定义了两种小鼠CD 4+效应/记忆T细胞亚群，它们分别通过相互表达粘附分子P-选择素配体（P-lig）和α4β7而优先定位于皮肤或肠淋巴器官。我们发现，在全身免疫的2天内，皮肤淋巴结中活化的CD 4 + T细胞上调P-lig，下调α4β7，而肠淋巴结中对抗原应答的CD 4 + T细胞选择性表达高水平的α4β7，并获得对肠趋化因子胸腺表达的趋化因子（TECK）的应答。因此，在免疫应答期间，皮肤和肠次级淋巴器官内的局部微环境差异地指导这些粘附和化学引诱物受体的T细胞表达，将所得效应T细胞靶向发炎的皮肤或肠固有层。
Effector and memory T cells can be subdivided based on their ability to traffic through peripheral tissues such as inflamed skin and intestinal lamina propria, a property controlled by expression of ‘tissue-specific’ adhesion and chemoattractant receptors. However, little is known about the development of these selectively homing T cell subsets, and it is unclear whether activation in cutaneous versus intestinal lymphoid organs directly results in effector/memory T cells that differentially express adhesion and chemoattracant receptors targeting them to the corresponding nonlymphoid site. We define two murine CD4+ effector/memory T cell subsets that preferentially localize in cutaneous or intestinal lymphoid organs by their reciprocal expression of the adhesion molecules P-selectin ligand (P-lig) and α4β7, respectively. We show that within 2 d of systemic immunization CD4+ T cells activated in cutaneous lymph nodes upregulate P-lig, and downregulate α4β7, while those responding to antigen in intestinal lymph nodes selectively express high levels of α4β7 and acquire responsiveness to the intestinal chemokine thymus-expressed chemokine (TECK). Thus, during an immune response, local microenvironments within cutaneous and intestinal secondary lymphoid organs differentially direct T cell expression of these adhesion and chemoattractant receptors, targeting the resulting effector T cells to the inflamed skin or intestinal lamina propria.
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DOI：
10.1084/jem.171.4.979
发表时间：
1990-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Daynes RA;Araneo BA;Dowell TA;Huang K;Dudley D
通讯作者：
Dudley D
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
影响因子：
64.8
作者：
Austrup, F;Vestweber, D;Hamann, A
通讯作者：
Hamann, A
DOI：
10.1083/jcb.141.4.1053
发表时间：
1998-05-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Campbell JJ;Bowman EP;Murphy K;Youngman KR;Siani MA;Thompson DA;Wu L;Zlotnik A;Butcher EC
通讯作者：
Butcher EC
影响因子：
32.4
作者：
KEARNEY, ER;PAPE, KA;JENKINS, MK
通讯作者：
JENKINS, MK