REDfly 2.0: an integrated database of cis-regulatory modules and transcription factor binding sites in Drosophila.
REDfly 2.0: an integrated database of cis-regulatory modules and transcription factor binding sites in Drosophila.
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DOI：
10.1093/nar/gkm876
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Bergman CM
中科院分区：
文献类型：
--
作者：
Halfon MS;Gallo SM;Bergman CM
控制基因表达的顺式调控元件的鉴定和研究是生物学研究的重要领域，但很少有资源可以促进后生动物物种顺式调控的大规模生物信息学研究。黑颊果蝇具有良好的基因组注释、独特的比较基因组资源和悠久的转录调控实验研究历史，是调控生物信息学的理想系统。我们将两个现有的果蝇资源，即REDfly的顺式调控模块数据库和FlyReg的转录因子结合位点（TFBSs）数据库合并为一个集成数据库，其中包含大量经经验验证的顺式调控模块及其组成结合位点的注释。通过将TFBS数据整合到REDfly中，增强的功能成为可能，同时对REDfly基础设施进行了额外的改进，我们已经构建了一个一站式的果蝇调控数据门户，这将成为转录调控计算和实验研究的强大资源。REDfly可以在http://redfly.ccr.buffalo.edu免费访问。
The identification and study of the cis-regulatory elements that control gene expression are important areas of biological research, but few resources exist to facilitate large-scale bioinformatics studies of cis-regulation in metazoan species. Drosophila melanogaster, with its well-annotated genome, exceptional resources for comparative genomics and long history of experimental studies of transcriptional regulation, represents the ideal system for regulatory bioinformatics. We have merged two existing Drosophila resources, the REDfly database of cis-regulatory modules and the FlyReg database of transcription factor binding sites (TFBSs), into a single integrated database containing extensive annotation of empirically validated cis-regulatory modules and their constituent binding sites. With the enhanced functionality made possible through this integration of TFBS data into REDfly, together with additional improvements to the REDfly infrastructure, we have constructed a one-stop portal for Drosophila cis-regulatory data that will serve as a powerful resource for both computational and experimental studies of transcriptional regulation. REDfly is freely accessible at http://redfly.ccr.buffalo.edu.
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影响因子：
14.9
作者：
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