miR-618 Inhibits Prostate Cancer Migration and Invasion by Targeting FOXP2.
miR-618 Inhibits Prostate Cancer Migration and Invasion by Targeting FOXP2.
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miR-618 通过靶向 FOXP2 抑制前列腺癌迁移和侵袭
DOI：
10.7150/jca.17407
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发表时间：
2017
影响因子：
3.9
通讯作者：
Wu ZQ
中科院分区：
文献类型：
--
作者：
Song XL;Tang Y;Lei XH;Zhao SC;Wu ZQ
miRNAs在前列腺癌的发生和发展中起关键作用。在这里，我们研究了miR-618在前列腺癌迁移和侵袭中的作用。miR-618在转移性雄激素非依赖性前列腺癌（AIPC）中下调，低miR-618的患者预后较差。miR-618的过表达抑制迁移和侵袭，并诱导间充质向上皮转化（MET）。相反，miR-618的敲低促进迁移和侵袭，并诱导上皮向间充质转化（EMT）。FOXP 2是miR-618的直接靶点，并促进TGF-β的表达，抑制TGF-β可逆转miR-618敲低的作用。我们进一步分析了miR-618在人前列腺癌组织中的表达与FOXP 2的相关性，发现miR-618的表达与FOXP 2水平呈负相关。总之，我们发现miR-618通过靶向FOXP 2和抑制TGF-β抑制前列腺癌的迁移和侵袭。
miRNAs play critical role in the development and progression of prostate cancer. Here we studied the role of miR-618 in prostate cancer migration and invasion. miR-618 was downregulated in metastatic androgen-independent prostate cancer (AIPC), patients with low miR-618 had poor outcome. Overexpression of miR-618 inhibited migration and invasion and induced mesenchymal to epithelial transition (MET). Conversely, knockdown of miR-618 promoted migration and invasion and induced epithelial to mesenchymal transition (EMT). FOXP2 was the direct target of miR-618, and promoted TGF-β expression, inhibition of TGF-β reversed the effect of miR-618 knockdown. We further analyzed the correlation between miR-618 expression and FOXP2 in human prostate cancer tissues, and found there was a negative correlation between miR-618 expression and FOXP2 levels. In conclusion, we found miR-618 inhibited prostate cancer migration and invasion by targeting FOXP2 and inhibiting TGF-β.
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