Granulocytosis
Granulocytosis
复制标题
粒细胞增多症
DOI：
10.1007/978-3-030-49980-8_14
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
D. Kamat
中科院分区：
文献类型：
--
作者：
Aarti Kamat;D. Kamat
粒细胞是含有颗粒的白细胞。粒细胞增多可能是由于中性粒细胞计数（嗜中性粒细胞）增加，嗜酸性粒细胞计数（嗜酸性粒细胞）增加，或嗜碱性粒细胞计数（嗜碱性粒细胞）增加。中性粒细胞计数的增加是由多种机制引起的，包括骨髓中产生的增加、骨髓储存部位释放的增加、进入循环的脱界增加、从循环中退出的减少和脱界减少。中性粒细胞增多的每一种机制都有许多原因，通常单一的病因可能通过多种机制导致中性粒细胞增多。最常见的中性粒细胞类型是反应性中性粒细胞，可急性或慢性。原发性中性粒细胞增多症是罕见的，是骨髓中性粒细胞产生异常调节的结果。嗜酸性粒细胞不像嗜中性粒细胞那么常见。在美国，嗜酸性粒细胞增多症最常见的原因是过敏性疾病，而在发展中国家，它是寄生虫感染。在家族性嗜酸性粒细胞综合征中，由于嗜酸性粒细胞产生不平衡，嗜酸性粒细胞发生在其他健康患者身上。孤立性嗜碱性粒细胞增多症很少见，但见于缺铁性贫血、慢性炎症和某些感染患者。在大多数情况下，识别和治疗潜在的原因可以适当地解决粒细胞增多症。
Granulocytes are white blood cells which contain granules. Granulocytosis could be due to an increase in neutrophil count (neutrophilia), an increase in eosinophil count (eosinophilia), or an increase in basophil count (basophilia). The neutrophil count increases by a number of mechanisms including increased production in the bone marrow, increased release from bone marrow storage sites, increase in demargination into circulation, decrease in egress from circulation, and decrease in margination. Each of these mechanisms of neutrophilia has many causes, and often a single etiology may result in neutrophilia through multiple mechanisms. The most common type of neutrophilia is reactive neutrophilia and can be acute or chronic. Primary neutrophilia is uncommon and results from abnormal regulation of neutrophil production in the bone marrow. Eosinophilia is not as common as neutrophilia. The most common cause of eosinophilia in the USA is allergic disorders, while in developing countries, it is the parasitic infestations. In familial eosinophilia syndrome, eosinophilia occurs in otherwise healthy patients due to an imbalance in eosinophil production. Isolated basophilia is rare but is seen in patients with iron deficiency anemia, chronic inflammatory conditions, and some infections. Identifying and treating the underlying cause appropriately resolves granulocytosis in most instances.
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DOI：
10.1097/00043426-198821000-00010
发表时间：
1988
期刊：
The American journal of pediatric hematology/oncology
影响因子：
--
作者：
Hedberg,VA;Lipton,JM
通讯作者：
Lipton,JM
影响因子：
2.6
作者：
Williams KW;Milner JD;Freeman AF
通讯作者：
Freeman AF
旅行者嗜酸性粒细胞增多。
DOI：
10.1016/s0025-7125(16)30294-2
发表时间：
1992
期刊：
The Medical clinics of North America
影响因子：
--
作者：
Weller,PF
通讯作者：
Weller,PF
影响因子：
2.6
作者：
Mehta P;Furuta GT
通讯作者：
Furuta GT