Practical guidelines for handling head and neck computed tomography artifacts for quantitative image analysis.
Practical guidelines for handling head and neck computed tomography artifacts for quantitative image analysis.
复制标题
DOI：
10.1016/j.compmedimag.2018.09.002
复制
发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Court LE
中科院分区：
文献类型：
--
作者：
Ger RB;Craft DF;Mackin DS;Zhou S;Layman RR;Jones AK;Elhalawani H;Fuller CD;Howell RM;Li H;Stafford RJ;Court LE
放射组学研究表明，定量影像特征可能用于改善头颈癌患者的预后分层。可以影响放射组学特征值的成像方案参数已经被研究，但由患者内在因素引起的伪影的影响还没有被研究。在头颈部癌症患者中常见的两种这样的伪影是由牙齿填充引起的条纹伪影和由骨骼引起的射束硬化伪影。这项研究的目的是测试这些伪影的影响，如果需要，在头颈部放射组学研究中补偿这些伪影的方法。通过去除30例头颈癌患者CT图像上的大体肿瘤体积(GTV)切片来测试特征值的稳健性；这些图像没有条纹伪影或远离GTV的伪影。将每个特征值在GTV的百分比上的范围与全容量下的患者间变异性进行比较。为了确定射束硬化伪影的影响，我们扫描了一个模型，模型中有5个不同材料的墨盒，包裹在聚苯乙烯堆积物中。弹壳上有一个圆柱孔，里面要么有一根聚乳酸来模拟水，要么有一根聚氯乙烯来模拟骨骼。在每个与杆子齐平的弹壳中画出了一个感兴趣的区域。大多数功能都很强大，但删除了高达50%的原始GTV。当用聚乳酸棒或聚氯乙烯棒测量时，大多数特征值没有显著差异。在大多数情况下，差异的大小没有超过患者之间的标准偏差。我们的结论是，简单地移除受条纹伪影影响的切片可以使这些扫描包括在放射组学研究中，并且如果需要，结构的轮廓可以贴近骨骼而不受射束硬化的影响。
Radiomics studies have demonstrated the potential use of quantitative image features to improve prognostic stratification of patients with head and neck cancer. Imaging protocol parameters that can affect radiomics feature values have been investigated, but the effects of artifacts caused by intrinsic patient factors have not. Two such artifacts that are common in patients with head and neck cancer are streak artifacts caused by dental fillings and beam-hardening artifacts caused by bone. The purpose of this study was to test the impact of these artifacts and if needed, methods for compensating for these artifacts in head and neck radiomics studies. The robustness of feature values was tested by removing slices of the gross tumor volume (GTV) on computed tomography images from 30 patients with head and neck cancer; these images did not have streak artifacts or had artifacts far from the GTV. The range of each feature value over a percentage of the GTV was compared to the inter-patient variability at full volume. To determine the effects of beam-hardening artifacts, we scanned a phantom with 5 cartridges of different materials encased in polystyrene buildup. A cylindrical hole through the cartridges contained either a rod of polylactic acid to simulate water or a rod of polyvinyl chloride to simulate bone. A region of interest was drawn in each cartridge flush with the rod. Most features were robust with up to 50% of the original GTV removed. Most feature values did not significantly differ when measured with the polylactic acid rod or the polyvinyl chloride rod. Of those that did, the size of the difference did not exceed the inter-patient standard deviation in most cases. We conclude that simply removing slices affected by streak artifacts can enable these scans to be included in radiomics studies and that contours of structures can abut bone without being affected by beam hardening if needed.
登录
查看更多内容
影响因子：
3.8
作者：
Craft, Daniel F.;Kry, Stephen F.;Howell, Rebecca M.
通讯作者：
Howell, Rebecca M.
影响因子：
2.1
作者：
Craft DF;Howell RM
通讯作者：
Howell RM
影响因子：
4.6
作者：
Zhao B;Tan Y;Tsai WY;Qi J;Xie C;Lu L;Schwartz LH
通讯作者：
Schwartz LH
影响因子：
3.1
作者：
Bogowicz, Marta;Riesterer, Oliver;Tanadini-Lang, Stephanie
通讯作者：
Tanadini-Lang, Stephanie
影响因子：
4.6
作者：
Parmar C;Leijenaar RT;Grossmann P;Rios Velazquez E;Bussink J;Rietveld D;Rietbergen MM;Haibe-Kains B;Lambin P;Aerts HJ
通讯作者：
Aerts HJ