Preparation and fabrication of a full-scale, sagittal-sliced, 3D-printed, patient-specific radiotherapy phantom.
Preparation and fabrication of a full-scale, sagittal-sliced, 3D-printed, patient-specific radiotherapy phantom.
复制标题
DOI：
10.1002/acm2.12162
复制
发表时间：
2017-09
影响因子：
2.1
通讯作者：
Howell RM
中科院分区：
文献类型：
--
作者：
Craft DF;Howell RM
患者特异性3D打印的幻影在研究和临床方面都有许多潜在的应用。然而，由于大多数商用3D打印机的小尺寸以及材料翘曲问题，它们在尺寸和复杂性方面受到限制。我们的目标是通过开发和测试有效的3D打印工作流程来克服这些限制，以制造具有最小扭曲误差的大型患者特异性放疗幻影。在此过程中，我们制作了一个真实的乳房切除术后患者的全尺寸假体。我们将患者的临床CT DICOM数据转换为3D模型，然后将模型切成11个2.5 cm厚的矢状切片。这些切片是用一种容易获得的热塑性材料打印的，它代表了100%填充的所有身体组织，但空腔是开放的。每一片都是在廉价的商用3D打印机上打印出来的。一旦打印完成，将切片放在一起进行成像和验证。原始患者CT扫描和组装的幻影CT扫描一起登记以评估总体准确性。完成幻影的材料成本为524美元。打印的幻影与它的设计和实际的病人都很吻合。单个切片与他们的设计相差约2%。装配后的假体与原患者的注册CT图像显示出极好的一致性。在矢状面切片上对患者特异性幻体进行三维打印，可以制造出高精度的大型幻体。我们的研究结果表明，我们的3D打印工作流程可用于制作大型，准确，患者特定的100%填充的幻影，并且材料翘曲误差最小。
Patient‐specific 3D‐printed phantoms have many potential applications, both research and clinical. However, they have been limited in size and complexity because of the small size of most commercially available 3D printers as well as material warping concerns. We aimed to overcome these limitations by developing and testing an effective 3D printing workflow to fabricate a large patient‐specific radiotherapy phantom with minimal warping errors. In doing so, we produced a full‐scale phantom of a real postmastectomy patient. We converted a patient's clinical CT DICOM data into a 3D model and then sliced the model into eleven 2.5‐cm‐thick sagittal slices. The slices were printed with a readily available thermoplastic material representing all body tissues at 100% infill, but with air cavities left open. Each slice was printed on an inexpensive and commercially available 3D printer. Once the printing was completed, the slices were placed together for imaging and verification. The original patient CT scan and the assembled phantom CT scan were registered together to assess overall accuracy. The materials for the completed phantom cost $524. The printed phantom agreed well with both its design and the actual patient. Individual slices differed from their designs by approximately 2%. Registered CT images of the assembled phantom and original patient showed excellent agreement. Three‐dimensional printing the patient‐specific phantom in sagittal slices allowed a large phantom to be fabricated with high accuracy. Our results demonstrate that our 3D printing workflow can be used to make large, accurate, patient‐specific phantoms at 100% infill with minimal material warping error.
登录
查看更多内容
影响因子：
2.7
作者：
Radecka, E;Brehmer, M;Magnusson, A
通讯作者：
Magnusson, A
DOI：
10.1016/j.ijrobp.2007.08.083
发表时间：
2008-01-01
影响因子：
7
作者：
Ibbott, Geoffrey S.;Followill, David S.;Roll, Joys E.
通讯作者：
Roll, Joys E.
影响因子：
2.9
作者：
Watson, Robert A.
通讯作者：
Watson, Robert A.
影响因子：
3.8
作者：
Gear, J. I.;Long, C.;Flux, G. D.
通讯作者：
Flux, G. D.
影响因子：
2.1
作者：
Burleson S;Baker J;Hsia AT;Xu Z
通讯作者：
Xu Z