GEISHA: an evolving gene expression resource for the chicken embryo.

GEISHA: an evolving gene expression resource for the chicken embryo.
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DOI:
10.1093/nar/gkt962
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发表时间:
2014-01
影响因子:
14.9
通讯作者:
Darnell DK
Darnell DK
中科院分区:
生物学2区
文献类型:
--
作者:
Antin PB;Yatskievych TA;Davey S;Darnell DK

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GEISHA (Gallus Expression In Situ Hybridization Analysis; http://geisha.arizona.edu)是鸡胚的原位杂交基因表达和基因组资源。此更新描述了增强其对用户的实用性的修改。在过去的5年中,GEISHA进行了重大的重组,以更紧密地符合其他物种模式生物数据库的数据组织和格式。这涉及到从以入口为中心的格式向以基因为中心的格式的迁移。数据库重组使得包含与鸡基因和蛋白质及其在其他物种中的同源物有关的数据成为可能。这些新信息通过更新后的用户界面呈现。将小鼠、青蛙、斑马鱼和果蝇的原位杂交数据与鸡的基因组和表达信息相结合。一个整合了GEISHA接口信息和在线孟德尔遗传人类疾病基因数据库的资源也被开发出来。最后,鸡基因命名委员会数据库和GEISHA数据库已被整合,以便它们从相同的数据资源中提取。
GEISHA (Gallus Expression In Situ Hybridization Analysis; http://geisha.arizona.edu) is an in situ hybridization gene expression and genomic resource for the chicken embryo. This update describes modifications that enhance its utility to users. During the past 5 years, GEISHA has undertaken a significant restructuring to more closely conform to the data organization and formatting of Model Organism Databases in other species. This has involved migrating from an entry-centric format to one that is gene-centered. Database restructuring has enabled the inclusion of data pertaining to chicken genes and proteins and their orthologs in other species. This new information is presented through an updated user interface. In situ hybridization data in mouse, frog, zebrafish and fruitfly are integrated with chicken genomic and expression information. A resource has also been developed that integrates the GEISHA interface information with the Online Mendelian Inheritance in Man human disease gene database. Finally, the Chicken Gene Nomenclature Committee database and the GEISHA database have been integrated so that they draw from the same data resources.
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