A Cognitive Neuroscience View of Schizophrenic Symptoms: Abnormal Activation of a System for Social Perception and Communication.

A Cognitive Neuroscience View of Schizophrenic Symptoms: Abnormal Activation of a System for Social Perception and Communication.
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精神分裂症症状的认知神经科学观点:社会感知和沟通系统的异常激活。

DOI:
10.1007/s11682-008-9052-1
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发表时间:
2009
影响因子:
3.2
通讯作者:
Hashimoto,Ryuichiro
Hashimoto,Ryuichiro
中科院分区:
医学3区
文献类型:
--
作者:
Wible,CynthiaG;Preus,AlexanderP;Hashimoto,Ryuichiro

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我们将审查收敛的证据表明,语言相关的精神分裂症综合征的症状,如幻听,至少部分来自后语言区域的处理异常。这些语言区域与(后)颞叶皮层和颞顶叶枕叶交界处的区域相邻或重叠,这些区域是处理社会认知、情感和自我表征或代理的系统的一部分。下顶骨和后上级颞区包含多模态表征系统,也可以提供快速反馈和前馈激活的单峰区域,如听觉皮层。我们认为,这些区域的过度激活不仅可能导致语义和言语(听觉词)表征的错误激活,导致思维障碍和幻听,而且还可能导致精神分裂症的许多其他症状。这些区域也是所谓的“默认网络”的一部分,默认网络是一个通常活跃的区域网络;它们的活动也与海马系统内的活动相关。
We will review converging evidence that language related symptoms of the schizophrenic syndrome such as auditory verbal hallucinations arise at least in part from processing abnormalities in posterior language regions. These language regions are either adjacent to or overlapping with regions in the (posterior) temporal cortex and temporo-parietal occipital junction that are part of a system for processing social cognition, emotion, and self representation or agency. The inferior parietal and posterior superior temporal regions contain multi-modal representational systems that may also provide rapid feedback and feed-forward activation to unimodal regions such as auditory cortex. We propose that the over-activation of these regions could not only result in erroneous activation of semantic and speech (auditory word) representations, resulting in thought disorder and voice hallucinations, but could also result in many of the other symptoms of schizophrenia. These regions are also part of the so-called “default network”, a network of regions that are normally active; and their activity is also correlated with activity within the hippocampal system.
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