Ion channels and early development of neural cells.
Ion channels and early development of neural cells.
复制标题
离子通道和神经细胞的早期发育。
作者：
Kunitaro Takahashi;Y. Okamura
In this review we underscore the merits of using voltage-dependent ion channels as markers for neuronal differentiation from the early stages of uncommitted embryonic blastomeres. Furthermore, a fairly large part of the review is devoted to the descriptions of the establishment of a simple model system for neural induction derived from the cleavage-arrested eight-cell ascidian embryo by pairing a single ectodermal with a single vegetal blastomere as a competent and an inducer cell, respectively. The descriptions are focused particularly on the early developmental processes of various ion channels in neuronal and other excitable membranes observed in this extraordinarily simple system, and we compare these results with those in other significant and definable systems for neural differentiation. It is stressed that this simple system, for which most of the electronic and optical methods and various injection experiments are applicable, may be useful for future molecular physiological studies on the intracellular process of differentiation of the early embryonic cells. We have also highlighted the importance of suppressive mechanisms for cellular differentiation from the experimental results, such as epidermal commitment of the cleavage-arrested one-cell Halocynthia embryos or suppression of epidermal-specific transcription of inward rectifier channels by neural induction signals. It was suggested that reciprocal suppressive mechanisms at the transcriptional level may be one of the key processes for cellular differentiation, by which exclusivity of cell types is maintained.
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大鼠妊娠期间参与胎母通讯的三种间隙连接基因产物的时空表达。
DOI：
10.1242/dev.113.1.165
发表时间：
1991
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Risek,B;Gilula,NB
通讯作者：
Gilula,NB
影响因子：
56.9
作者：
FIELD, KG;OLSEN, GJ;RAFF, RA
通讯作者：
RAFF, RA
DOI：
10.1073/pnas.94.4.1177
发表时间：
1997-02
影响因子：
11.1
作者：
José Tapia-Ramirez;Bart J. L. Eggen;Maria J. Peral-Rubio;J. Toledo-Aral;J. Toledo-Aral;Gail Mandel
通讯作者：
José Tapia-Ramirez;Bart J. L. Eggen;Maria J. Peral-Rubio;J. Toledo-Aral;J. Toledo-Aral;Gail Mandel
DOI：
10.1016/s0021-9258(17)38689-1
发表时间：
1985-11
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
M. Greenberg;L. Greene;E. Ziff
通讯作者：
M. Greenberg;L. Greene;E. Ziff
细胞骨架抑制剂对 Chaetopterus pergamentaceus 细胞质定位的影响。
DOI：
10.1111/j.1432-0436.1981.tb01127.x
发表时间：
1981
期刊：
Differentiation; research in biological diversity
影响因子：
--
作者：
Eckberg,WR
通讯作者：
Eckberg,WR