Neighborhood psychosocial environment, apolipoprotein E genotype, and cognitive function in older adults.
Neighborhood psychosocial environment, apolipoprotein E genotype, and cognitive function in older adults.
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DOI：
10.1001/archgenpsychiatry.2011.6
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发表时间：
2011-03
影响因子：
--
通讯作者：
Schwartz, Brian S.
中科院分区：
文献类型：
--
作者：
Lee, Brian K.;Glass, Thomas A.;James, Bryan D.;Bandeen-Roche, Karen;Schwartz, Brian S.
社会环境可能会影响老年人的认知功能。然而，据我们所知，没有研究调查是否特定的基因修改这种关联。研究载脂蛋白E（APOE）基因<$4等位基因是否改变了邻里心理社会危险因素与认知功能的关系。横向分析。巴尔的摩记忆研究，一个基于人口的老年城市居民样本。巴尔的摩市的65个研究社区的特点是使用邻里心理社会危害量表，旨在评估社会混乱，身体障碍，公共安全和经济剥夺。基线年龄为50 - 70岁的城市居民1140人。测量了20项标准测试的认知表现，并将其组合形成7个领域评分汇总（语言、处理速度、手眼协调、执行功能、言语记忆和学习、视觉记忆和视觉构建）。在对个体协变量进行充分调整的分析中，我们发现高（即，更差）的邻居心理社会危害与更差的认知表现并不一致。然而，高邻里心理社会危害和APOE ε4基因型的相互作用被发现与更差的认知领域得分相关，在处理速度（p = 0.02）和执行功能（p < 0.001）领域有关联的证据。还发现了眼手协调的暗示性证据（p = 0.05）。生活在社会心理危险的社区与APOE ε4等位基因携带者的认知功能较差相关，这是一种新的基因x环境相互作用的证据。
The social environment may influence cognitive function in aging. However, to our knowledge, no studies have investigated whether specific genes modify this association. To examine whether the apolipoprotein E (APOE) epsilon-4 allele modified the associations of neighborhood psychosocial hazards and cognitive function. A cross-sectional analysis. The Baltimore Memory Study, a population-based sample of older urban residents. The 65 study neighborhoods in Baltimore city were characterized using the Neighborhood Psychosocial Hazards scale, designed to assess social disorganization, physical disorder, public safety, and economic deprivation. One thousand one hundred forty urban residents aged 50 to 70 years at baseline. Cognitive performance on 20 standard tests was measured and combined to form 7 summary domain scores (language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, visual memory, and visuoconstruction). In analyses fully adjusted for individual covariates, we found that high (i.e., worse) neighborhood psychosocial hazards were not consistently associated with worse cognitive performance. However, the interaction of high neighborhood psychosocial hazards and APOE ε4 genotype was found to be associated with worse cognitive domain scores, with evidence of associations in the domains of processing speed (p = 0.02) and executive functioning (p < 0.001). Suggestive evidence was also found for eye-hand coordination (p = 0.05). Living in a psychosocially hazardous neighborhood was associated with worse cognitive function in persons with the APOE ε4 allele, evidence of a novel gene x environment interaction.
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