Eccentric muscle damage transiently decreases rat skeletal muscle GLUT-4 protein.
Eccentric muscle damage transiently decreases rat skeletal muscle GLUT-4 protein.
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偏心肌肉损伤会暂时降低大鼠骨骼肌 GLUT-4 蛋白。
DOI：
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发表时间：
1995
影响因子：
3.3
通讯作者：
Erik A. Richter
中科院分区：
文献类型：
--
作者：
S. Asp;S. Kristiansen;Erik A. Richter
在大鼠肌肉中研究了向心收缩和肌肉损伤性离心收缩对肌肉葡萄糖转运蛋白 GLUT-4 含量的影响。将大鼠麻醉，电刺激一侧小腿肌肉进行向心或离心收缩，运动后获取双侧小腿肌肉。炎症和吞噬细胞在偏心白色和红色腓肠肌中积累，而偏心比目鱼肌中仅存在离散变化。两种类型的刺激后，白色和红色腓肠肌中的糖原消耗程度相同，并且偏心肌肉中的糖原保持下降> 2天。偏心刺激后1天和2天，偏心白色和红色腓肠肌中总GLUT-4蛋白含量下降，而糖原合酶的最大活性在这些时间点不受影响。总之，我们的单腿刺激模型导致白色和红色腓肠肌出现偏心肌肉损伤，而比目鱼肌仅观察到轻微损伤。在受损的肌肉中，肌糖原和 GLUT-4 蛋白含量下降超过 2 天。这些发现可能表明（但并未证明）肌肉 GLUT-4 蛋白的减少与离心运动后糖原再合成延迟有关。
The effects of concentric and muscle-damaging eccentric contractions on muscle glucose transporter GLUT-4 content were studied in rat muscles. Rats were anesthetized, the calf muscles on one side were stimulated electrically for concentric or eccentric contractions, and bilateral calf muscles were obtained in the postexercise period. Inflammatory and phagocytic cells accumulated in the eccentric white and red gastrocnemius muscles, whereas there were only discrete changes in the eccentric soleus. Glycogen was depleted to the same extent in the white and red gastrocnemius muscles after both types of stimulation, and it remained decreased > 2 days in eccentric muscles. The total GLUT-4 protein content was decreased in the eccentric white and red gastrocnemius muscles 1 and 2 days after the eccentric stimulation, whereas the maximal activity of glycogen synthase was unaffected at these time points. In conclusion, our one-legged stimulation model caused eccentric muscle damage in the white and red gastrocnemius, whereas only minor damage was observed in the soleus muscle. In damaged muscle, muscle glycogen and GLUT-4 protein content were decreased for > 2 days. These findings may suggest (but do not prove) that decreased muscle GLUT-4 protein is involved in the delayed glycogen resynthesis after eccentric exercise.
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离心运动会导致健康个体出现短暂的胰岛素抵抗。
DOI：
10.1152/jappl.1992.72.6.2197
发表时间：
1992
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Kirwan,JP;Hickner,RC;Yarasheski,KE;Kohrt,WM;Wiethop,BV;Holloszy,JO
通讯作者：
Holloszy,JO
DOI：
10.1016/s0021-9258(18)77362-6
发表时间：
1990-08
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
A. Douen;T. Ramlal;Sanjay Rastogi;P. Bilan;G. Cartee;M. Vranic;J. Holloszy;A. Klip
通讯作者：
A. Douen;T. Ramlal;Sanjay Rastogi;P. Bilan;G. Cartee;M. Vranic;J. Holloszy;A. Klip
影响因子：
--
作者：
RICHTER, EA;GARETTO, LP;RUDERMAN, NB
通讯作者：
RUDERMAN, NB
运动会导致肌肉中 GLUT4 表达、葡萄糖转运能力和胰岛素刺激的糖原储存快速增加。
DOI：
--
发表时间：
1994
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Ren,JM;Semenkovich,CF;Gulve,EA;Gao,J;Holloszy,JO
通讯作者：
Holloszy,JO
DOI：
--
发表时间：
1993-08
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
J. Ren;B. Marshall;E. Gulve;Jiaping Gao;David W. Johnson;J. Holloszy;M. Mueckler
通讯作者：
J. Ren;B. Marshall;E. Gulve;Jiaping Gao;David W. Johnson;J. Holloszy;M. Mueckler