Neural signature of flexible coding in prefrontal cortex.
Neural signature of flexible coding in prefrontal cortex.
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DOI：
10.1073/pnas.2200400119
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发表时间：
2022-10-04
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
神经选择性的快速变化被认为是存储新关联的潜在机制。尽管这种潜在的机制在计算模型中得到了很好的认可，但仍然缺乏直接的神经证据。在这里，我们表明，特征审判到审判的神经选择性的变化所产生的工作记忆模型实现快速Hebbian突触可塑性也存在于前额叶皮层神经种群的猴子执行工作记忆任务。使用trialwise模式相似性的方法来跟踪这些变化的编码过程中的协会，我们表明，神经选择性的变化遵循一个新的刺激，打破了以前的刺激的功能之间的关联的编码。前额叶皮质快速编码新关联的能力对于适应行为至关重要，也是工作记忆的核心。突触强度的快速赫布变化允许形成新的关联，但这种关联的神经元特征一直难以捉摸。我们设计了一个模式相似性的试验指数，以寻找人口代码的快速变化。基于工作记忆的计算模型，我们假设，如果后续刺激的特征需要“重新关联”，即，如果需要打破特征之间的绑定以编码新项目，因此，相同的刺激可能会引起不同的神经反应。正如预测的那样，神经反应的相似性在重新绑定后下降，但仅在前额叶皮层。历史依赖性变化是在传统的、固定的选择性之上表达的，并且不能通过将先前的击发遗留到当前试验中或通过神经适应来解释。
Rapid changes in neural selectivity have been proposed as a potential mechanism for storing novel associations. Despite this potential mechanism’s being well-recognized in computational models, direct neural evidence is still lacking. Here, we show that characteristic trial-to-trial changes in neural selectivity generated by a working memory model implementing fast Hebbian synaptic plasticity are also present in prefrontal cortex neural populations of monkeys performing a working memory task. Using a trialwise pattern similarity method to track these changes during the encoding of associations, we show that changes in neural selectivity followed the encoding of a new stimulus that breaks down an association between the features of a previous stimulus. The ability of prefrontal cortex to quickly encode novel associations is crucial for adaptive behavior and central to working memory. Fast Hebbian changes in synaptic strength permit forming new associations, but neuronal signatures of this have been elusive. We devised a trialwise index of pattern similarity to look for rapid changes in population codes. Based on a computational model of working memory, we hypothesized that synaptic strength—and consequently, the tuning of neurons—could change if features of a subsequent stimulus need to be “reassociated,” i.e., if bindings between features need to be broken to encode the new item. As a result, identical stimuli might elicit different neural responses. As predicted, neural response similarity dropped following rebinding, but only in prefrontal cortex. The history-dependent changes were expressed on top of traditional, fixed selectivity and were not explainable by carryover of previous firing into the current trial or by neural adaptation.
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DOI：
10.1098/rstb.2013.0131
发表时间：
2014-01-05
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Park P;Volianskis A;Sanderson TM;Bortolotto ZA;Jane DE;Zhuo M;Kaang BK;Collingridge GL
通讯作者：
Collingridge GL
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.4
作者：
Polyn, Sean M.;Norman, Kenneth A.;Kahana, Michael J.
通讯作者：
Kahana, Michael J.
影响因子：
3.2
作者：
Erickson MA;Maramara LA;Lisman J
通讯作者：
Lisman J
影响因子：
16.2
作者：
Bouchacourt, Flora;Buschman, Timothy J.
通讯作者：
Buschman, Timothy J.