Targeting epigenetic mediators of gene expression in thoracic malignancies.
Targeting epigenetic mediators of gene expression in thoracic malignancies.
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DOI：
10.1016/j.bbagrm.2012.03.009
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Schrump DS
中科院分区：
文献类型：
--
作者：
Schrump DS
Lung and esophageal cancers and malignant pleural mesotheliomas are highly lethal neoplasms that are leading causes of cancer-related deaths worldwide. Presently, limited information is available pertaining to epi-genetic mechanisms mediating initiation and progression of these neoplasms. The following presentation will focus on the potential clinical relevance of epigenomic alterations in thoracic malignancies mediated by DNA methylation, perturbations in the histone code, and polycomb group proteins, as well as ongoing translational efforts to target epigenetic regulators of gene expression for treatment of these neoplasms.
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作者：
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DOI：
10.4049/jimmunol.1001775
发表时间：
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期刊：
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DOI：
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发表时间：
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期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
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