Changes of plasma atrial and brain natriuretic peptide levels during hemodialysis.
Changes of plasma atrial and brain natriuretic peptide levels during hemodialysis.
复制标题
血液透析期间血浆心房和脑钠尿肽水平的变化。
DOI：
10.3109/08860229609052796
复制
发表时间：
1996
期刊：
影响因子：
3
通讯作者：
K. Miyatake
中科院分区：
文献类型：
--
作者：
F. Ishikura;Yutaka Ando;Yung;A. Tani;Dairoku Shirai;H. Matsuoka;K. Miyatake
目标
本研究旨在评价血液透析对慢性肾功能衰竭患者血浆心钠素和脑钠素浓度的影响，并确定影响血浆心钠素和脑钠素水平变化的二维超声心动图参数。
背景
脑利钠肽存在于人体心脏组织中，在充血性心力衰竭患者中含量增加。然而，刺激血浆脑钠肽分泌的因素尚未完全阐明。
方法
对15例慢性肾功能衰竭患者进行血液透析前后的血浆心钠素、脑钠素水平及二维超声心动图参数的测定。
结果
血液透析后血浆心钠素水平从367 +/- 537 pg/mL显著降低至138 +/- 167 pg/mL（p < 0.01）。然而，血液透析后血浆脑钠肽水平没有显着变化。血液透析后左心房内径显著减小（41.1 ± 6.6 mm vs. 36.3 ± 6.2 mm，p < 0.01），左心室舒张末期内径略有减小（57.0 ± 10.3 mm vs. 55.7 ± 9.9 mm，p < 0.05）。左房内径的减小大于左室舒张末期内径的减小（4.9 ± 1.6mm vs.1.3 ± 0.6mm，p < 0.05）。血透前后血浆脑钠素水平与短轴缩短率均呈显著相关（r = 0.65，p < 0.05）。
结论
血浆心钠素水平随着右心房和左心房超负荷的降低而显著降低，血液透析后血浆脑钠素水平没有显著降低。血液透析等急性血液动力学改变对血浆脑钠素水平无明显影响。而血浆脑钠肽水平与基础心功能显著相关。
OBJECTIVES
The purpose of this study was to evaluate the effect of hemodialysis on the plasma concentration of atrial and brain natriuretic peptides, and to determine the two-dimensional echocardiographic parameters affecting the changes of plasma atrial and brain natriuretic peptide levels in patients with chronic renal failure.
BACKGROUND
Brain natriuretic peptide has been found in human cardiac tissue and increases in patients with congestive heart failure. However, the factors that stimulate the secretion of plasma brain natriuretic peptide have not yet been fully clarified.
METHODS
In 15 patients with chronic renal failure, plasma atrial and brain natriuretic peptide levels and two-dimensional echocardiographic parameters were measured before and after each session of hemodialysis.
RESULTS
Plasma atrial natriuretic peptide levels significantly decreased from 367 +/- 537 pg/mL to 138 +/- 167 pg/mL after hemodialysis (p < 0.01). However, plasma brain natriuretic peptide levels did not significantly change after hemodialysis. Left atrial dimension significantly decreased (41.1 +/- 6.6 vs. 36.3 +/- 6.2 mm, p < 0.01) and left ventricular end-diastolic dimension slightly decreased after hemodialysis (57.0 +/- 10.3 vs. 55.7 +/- 9.9 mm, p < 0.05). The decrease of left atrial dimension was greater than that of left ventricular end-diastolic dimension (4.9 +/- 1.6 vs. 1.3 +/- 0.6 mm, p < 0.05). Plasma brain natriuretic peptide levels significantly correlated with fractional shortening both before and after hemodialysis (r = 0.65, p < 0.05).
CONCLUSION
Plasma atrial natriuretic peptide levels significantly decreased as the right and left atrial overloads decreased, and plasma brain natriuretic peptide levels did not significantly decrease after hemodialysis. Plasma brain natriuretic peptide levels were not significantly influenced by acute hemodynamic change, such as hemodialysis. However, plasma brain natriuretic peptide levels were significantly correlated with basic cardiac function.
人体免疫反应性心房钠尿激素血浆水平与血流动力学功能之间的关系。
影响因子：
37.8
作者：
Bates,ER;Shenker,Y;Grekin,RJ
通讯作者：
Grekin,RJ