The relationship between plasma levels of immunoreactive atrial natriuretic hormone and hemodynamic function in man.
The relationship between plasma levels of immunoreactive atrial natriuretic hormone and hemodynamic function in man.
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人体免疫反应性心房钠尿激素血浆水平与血流动力学功能之间的关系。
DOI：
10.1161/01.cir.73.6.1155
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发表时间：
1986
期刊：
影响因子：
37.8
通讯作者：
Grekin,RJ
中科院分区：
文献类型：
--
作者：
Bates,ER;Shenker,Y;Grekin,RJ
为了评价人血浆免疫反应性房钠素（IR-ANH）水平与不同血流动力学参数的关系，我们研究了34例右心导管置入术患者。用放射免疫法测定股骨静脉（n = 28）、右心室（n = 27）和左心室（n = 17）血样中IR-ANH的血浆水平。发现右心房压、肺动脉楔压、心率和平均动脉压是独立且显著的IR-ANH血浆水平预测因子。右房压与两组右心室IR-ANH水平相关性最密切（r = 0.78, p > 0.05）。0.001)或股静脉IR-ANH水平（r = 0.52, p < 0.006）。5例孤立性左心衰患者IR-ANH水平升高与其右心房压水平不成比例。肺动脉楔压也与右心室IR-ANH水平相关（r = 0.46, p < 0.05）。002)和股静脉IR-ANH水平（r = 0.58, p < 0.002）。一例孤立性右心衰患者，尽管肺动脉楔压正常，但IR-ANH水平明显升高。右心室水平是股静脉水平的两倍，且密切相关（181 +/- 40 vs 90 +/- 20 pmol/l; r = 0.90, p < 0.001）。右心室和左心室水平几乎相同（155 +/- 46 vs 146 +/- 43 pmol/l; r = 0.99, p < 0.001）。容量过载状态的患者IR-ANH水平升高。（摘要删节250字）
To evaluate the relationship between plasma levels of immunoreactive atrial natriuretic hormone (IR-ANH) and different hemodynamic parameters in man, we studied 34 patients undergoing right heart catheterization. Plasma levels of IR-ANH in blood samples withdrawn from the femoral vein (n = 28), right ventricle (n = 27), and left ventricle (n = 17) were determined by radioimmunoassay. Right atrial pressure, pulmonary arterial wedge pressure, heart rate, and mean arterial pressure were found to be independent and significant predictors of IR-ANH plasma levels. The closest correlations were between right atrial pressure and either right ventricular IR-ANH levels (r = .78, p greater than .001) or femoral vein IR-ANH levels (r = .52, p less than .006). Five patients with isolated left ventricular failure had elevated IR-ANH levels out of proportion to their right atrial pressure levels. Pulmonary arterial wedge pressure also correlated with right ventricular IR-ANH levels (r = .46, p less than .002) and with femoral vein IR-ANH levels (r = .58, p less than .002). A single patient with isolated right heart failure had markedly elevated IR-ANH levels despite normal pulmonary arterial wedge pressure. Right ventricular levels were twice femoral vein levels and were closely correlated (181 +/- 40 vs 90 +/- 20 pmol/liter; r = .90, p less than .001). Right ventricular and left ventricular levels were almost identical (155 +/- 46 vs 146 +/- 43 pmol/liter; r = .99, p less than .001). Patients with volume overload states had elevated IR-ANH levels.(ABSTRACT TRUNCATED AT 250 WORDS)
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DOI：
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发表时间：
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期刊：
影响因子：
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