Design and performance of a multi-pinhole collimation device for small animal imaging with clinical SPECT and SPECT-CT scanners.
Design and performance of a multi-pinhole collimation device for small animal imaging with clinical SPECT and SPECT-CT scanners.
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DOI：
10.1088/0031-9155/53/15/012
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发表时间：
2008-08-07
影响因子：
3.5
通讯作者：
DiFilippo, Frank P.
中科院分区：
文献类型：
--
作者：
DiFilippo, Frank P.
开发了一种多针孔准直装置，其使用临床SPECT或SPECT-CT扫描仪的伽马相机探测器来产生高分辨率SPECT图像。该装置包括一个旋转的圆柱形准直器，具有22个钨针孔，直径为0.9 mm的孔径和准直器内的动物床，线性移动，以提供螺旋或有序子集轴向采样。CT图像也可以在SPECT-CT扫描仪上采集，用于图像配准和SPECT衰减校正。将器械放置在扫描仪的患者检查床上，而不连接到探测器或扫描仪机架。系统的几何形状是从点源数据校准到位，然后在图像重建过程中使用。使用测试体模扫描评价器械的SPECT成像性能。从重建点源图像的空间分辨率测量为0.6 mm半高全宽或更好。Micro-Derenzo体模图像证明了分辨0.7 mm直径棒图案的能力。Micro-Defrise体模的轴向平板显示良好。在视场中心，准直器效率超过0.05%，均匀体模的图像显示出可接受的均匀性和最小伪影。该设备的整体简单性和相对良好的成像性能使其成为专用小动物扫描仪的有趣的低成本替代品。
A multi-pinhole collimation device is developed that uses the gamma camera detectors of a clinical SPECT or SPECT-CT scanner to produce high resolution SPECT images. The device consists of a rotating cylindrical collimator having 22 tungsten pinholes with 0.9 mm diameter apertures and an animal bed inside the collimator that moves linearly to provide helical or ordered-subsets axial sampling. CT images also may be acquired on a SPECT-CT scanner for purposes of image co-registration and SPECT attenuation correction. The device is placed on the patient table of the scanner without attaching to the detectors or scanner gantry. The system geometry is calibrated in-place from point source data and is then used during image reconstruction. The SPECT imaging performance of the device is evaluated with test phantom scans. Spatial resolution from reconstructed point source images is measured to be 0.6 mm full width at half maximum or better. Micro-Derenzo phantom images demonstrate the ability to resolve 0.7 mm diameter rod patterns. The axial slabs of a Micro-Defrise phantom are visualized well. Collimator efficiency exceeds 0.05% at the center of the field of view, and images of a uniform phantom show acceptable uniformity and minimal artifact. The overall simplicity and relatively good imaging performance of the device make it an interesting low-cost alternative to dedicated small animal scanners.
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