Living with Metastatic Cancer: A Roadmap for Future Research.
Living with Metastatic Cancer: A Roadmap for Future Research.
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DOI：
10.3390/cancers12123684
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发表时间：
2020-12-08
期刊：
影响因子：
5.2
通讯作者：
Oswald L
中科院分区：
文献类型：
--
作者：
Tometich DB;Hyland KA;Soliman H;Jim HSL;Oswald L
虽然转移性癌症患者的寿命更长，但他们面临着可能干扰其生活质量的挑战。这些挑战包括疾病恶化、生存时间、症状、痛苦和财务问题。本审查文件的目的是描述一个框架，以指导今后应对这些挑战的努力。该框架包括风险因素（诱发因素），触发因素（促发因素）和反应（永久因素），这些因素有助于转移性癌症患者生活中问题的发生和维持。最后，我们建议未来的工作领域，以防止问题，管理触发器，并减少无益的反应。患有转移性癌症或转移生存与癌症生存不同，并且随着新的治疗方法增加生存时间而发生变化。本叙述性综述的目的是在一个概念框架内描述影响元生存挑战的因素，以指导未来的研究。这篇综述着重于疾病进展、生存时间、症状、痛苦、经济毒性和生活质量等具体的元生存结局。我们描述的诱发，沉淀和永存（3P）模型的元生存。了解有助于发展和维持元生存挑战的生物，心理和社会3P因素为未来的研究提供了路线图。该模型的意义包括通过靶向诱发因素进行预防，在转移性疾病发作后管理促发因素，以及治疗永久性因素以减轻症状并改善转移性生存的慢性期生活质量。这可以通过生物心理社会筛查工作、监测患者报告的结果、教育和沟通干预、跨学科症状管理、提前护理计划和行为干预来实现，以培养心理弹性。
Although people with metastatic cancer are living longer with their disease, they are faced with challenges that can interfere with their quality of life. These challenges include worsening disease, survival time, symptoms, distress, and financial problems. The aim of this review paper is to describe a framework to guide future efforts to address these challenges. The framework includes the risk factors (predisposing factors), triggers (precipitating factors), and responses (perpetuating factors) that contribute to the onset and maintenance of problems in living with metastatic cancer. We conclude by suggesting areas for future work to prevent problems, manage triggers, and reduce unhelpful responses. Living with metastatic cancer, or metavivorship, differs from cancer survivorship and has changed as novel treatments have increased survival time. The purpose of this narrative review is to describe factors that impact challenges in metavivorship within a conceptual framework to guide future research. This review focuses on the specific metavivorship outcomes of progressive disease, survival time, symptoms, distress, financial toxicity, and quality of life. We describe the predisposing, precipitating, and perpetuating (3P) model of metavivorship. Understanding the biological, psychological, and social 3P factors that contribute to the development and maintenance of challenges in metavivorship provides a roadmap for future research. Implications of this model include prevention by targeting predisposing factors, management of precipitating factors after onset of metastatic disease, and treatment of perpetuating factors to reduce symptoms and improve quality of life during the chronic phase of metavivorship. This can be accomplished through biopsychosocial screening efforts, monitoring of patient-reported outcomes, education and communication interventions, interdisciplinary symptom management, advance care planning, and behavioral interventions to cultivate psychological resilience.
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影响因子：
6.2
作者：
Badr, Hoda;Smith, Cardinale B.;Goldstein, Nathan E.;Gomez, Jorge E.;Redd, William H.
通讯作者：
Redd, William H.
影响因子：
10.3
作者：
Basch, Ethan;Jia, Xiaoyu;Schrag, Deborah
通讯作者：
Schrag, Deborah
影响因子：
2.2
作者：
Agarwal R;Epstein AS
通讯作者：
Epstein AS
影响因子：
5.1
作者：
Aschwanden, Damaris;Gerend, Mary A.;Terracciano, Antonio
通讯作者：
Terracciano, Antonio
影响因子：
3.9
作者：
Cardoso, Fatima;Harbeck, Nadia;Fenech, Doris
通讯作者：
Fenech, Doris