Variability of the Ki-67 proliferation index in gastroenteropancreatic neuroendocrine neoplasms - a single-center retrospective study.
Variability of the Ki-67 proliferation index in gastroenteropancreatic neuroendocrine neoplasms - a single-center retrospective study.
复制标题
胃肠胰神经内分泌肿瘤中Ki-67增殖指数的变异性——单中心回顾性研究
DOI：
10.1186/s12902-018-0274-y
复制
发表时间：
2018-07-28
影响因子：
2.7
通讯作者：
Lin R
中科院分区：
文献类型：
--
作者：
Shi H;Zhang Q;Han C;Zhen D;Lin R
背景：胃肠胰腺神经内分泌肿瘤（GEP-NEN）的Ki-67指数可能在整个病程中发生变化。然而，Ki-67变异性对GEP-NEN的确切影响仍然未知。本研究的目的是评估Ki-67水平在整个疾病过程中的变化，并探讨Ki-67指数变异性在GEP-NENs.Methods中的作用：从2009年7月至2018年2月在武汉协和医院治疗的514例GEP-NENs患者中选择30例具有多种病理学特征的患者进行评估。Ki-67指数在多个标本中进行了评估。单因素和多因素考克斯比例风险回归分析进行评估的各种临床和病理特征的预后意义。在30例获得多种病理标本的患者中，24例为原发性和转移性标本，6例为病程中采集的标本。53.3%的患者检测到Ki-67水平的变化，其中40%的患者Ki-67水平上调，13.3%的患者Ki-67水平下调。Kaplan-Meier生存分析显示，Ki-67变异组的总生存期较短（p = 0.0297）。考克斯回归分析表明，Ki-67变异性（p = 0.038）是唯一的独立预后因素的总survival.Conclusions：我们的数据表明，GEP-NEN和Ki-67变异性患者的预后较差。在转移部位或病程中重新评估Ki-67可能在预测GEP-NEN患者的预后中发挥作用。这一发现可能对如何监测和治疗GEP-NEN产生影响。
Background:The Ki-67 index in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) may change throughout the disease course. However, the definitive effect of Ki-67 variability on GEP-NENs remains unknown. The aims of this study were to evaluate changes in Ki-67 levels throughout the disease course and investigate the role of Ki-67 index variability in GEP-NENs.Methods:Specimens with multiple pathologies were evaluated from 30 patients who were selected from 514 patients with GEP-NENs, being treated at Wuhan Union Hospital from July 2009 to February 2018. The Ki-67 index was evaluated among multiple specimens over the disease course. Univariable and multivariable Cox proportional hazards regression analyses were performed to assess the prognostic significance of various clinical and histopathologic features.Results:Among the 514 patients with GEP-NENs, metastases were seen in 182 (35.41%). Among the 30 patients from whom specimens with multiple pathologies were obtained, 24 were both primary and metastatic specimens and six were specimens collected over the course of the disease. Changes in Ki-67 levels were detected in 53.3% of the patients, of whom 40% had up-regulated Ki-67 levels, and 13.3% had down-regulated Ki-67 levels. Kaplan-Meier survival analysis showed that the group with Ki-67 variability had a shorter overall survival (p = 0.0297). The Cox regression analysis indicated that Ki-67 variability (p = 0.038) was the only independent prognostic factor for overall survival.Conclusions:Our data suggest that patients with GEP-NENs and Ki-67 variability had a poorer prognosis. The re-assessment of Ki-67 at sites of metastasis or during the disease course might play a role in predicting the prognosis of patients with GEP-NENs. This finding could have implications for how GEP-NENs are monitored and treated.
登录
查看更多内容
影响因子：
8.8
作者：
Khan MS;Luong TV;Watkins J;Toumpanakis C;Caplin ME;Meyer T
通讯作者：
Meyer T
影响因子：
28.4
作者：
Dasari, Arvind;Shen, Chan;Yao, James C.
通讯作者：
Yao, James C.
影响因子：
2.6
作者：
Miller, H. C.;Drymousis, P.;Frilling, A.
通讯作者：
Frilling, A.
影响因子：
3.3
作者：
Dhall, Deepti;Mertens, Richard;Wolin, Edward
通讯作者：
Wolin, Edward
影响因子：
3.8
作者：
Singh, S.;Hallet, J.;Law, C. H. L.
通讯作者：
Law, C. H. L.