A comparison of Ki-67 and mitotic count as prognostic markers for metastatic pancreatic and midgut neuroendocrine neoplasms.
A comparison of Ki-67 and mitotic count as prognostic markers for metastatic pancreatic and midgut neuroendocrine neoplasms.
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DOI：
10.1038/bjc.2013.156
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发表时间：
2013-05-14
影响因子：
8.8
通讯作者：
Meyer T
中科院分区：
文献类型：
--
作者：
Khan MS;Luong TV;Watkins J;Toumpanakis C;Caplin ME;Meyer T
本研究的目的是比较有丝分裂计数（MC）和Ki-67增殖指数作为胰腺和中肠神经内分泌肿瘤（NEN）的预后标志物。招募了285例转移性NEN患者。根据欧洲神经内分泌肿瘤学会指南定义的Ki-67或MC，评估组织学分级之间的一致性，并评估Ki-67或MC的预后意义。当在胰腺和中肠NEN中使用Ki-67或MC时，等级分配分别存在44%和38%的差异。在多变量分析中，使用Ki-67而不是MC的分级是确定总生存率的重要预后因素（风险比：中肠G2 2.34，G3 15.1，胰腺G2 2.08，G3 11.3）。Ki-67的预后价值使用改良的分类得到改善（风险比：中肠G2 3.02，G3 22.1，胰腺G2 5.97，G3 33.8）。Ki-67和MC在肿瘤分级方面缺乏一致性。对于转移性胰腺和中肠NEN，根据Ki-67分级是比MC更好的预后标志物。我们建议单独使用Ki-67对胰腺和中肠NEN进行分级，目前对G1/G2肿瘤分类的阈值应从2%修改为5%。
The aim of this study was to compare mitotic count (MC) and Ki-67 proliferation index as prognostic markers in pancreatic and midgut neuroendocrine neoplasms (NENs). Two hundred eighty-five patients with metastatic NENs were recruited. Concordance between histological grade according to either Ki-67 or MC as defined by the European Neuroendocrine Tumour Society guidelines was assessed and the prognostic significance of Ki-67 or MC were evaluated. There was a discrepancy of 44 and 38% in grade assignment when using Ki-67 or MC in pancreatic and midgut NENs, respectively. In multivariate analysis, grade using Ki-67, but not MC, was a significant prognostic factor in determining overall survival (hazard ratios: midgut G2 2.34, G3 15.1, pancreas G2 2.08, G3 11.3). The prognostic value of Ki-67 was improved using a modified classification (hazard ratios: midgut G2 3.02, for G3 22.1, pancreas G2 5.97, G3 33.8). There is a lack of concordance between Ki-67 and MC in assigning tumour grade. Grade according to Ki-67 was a better prognostic marker than MC for metastatic pancreatic and midgut NENs. We suggest that Ki-67 alone should be used for grading pancreatic and midgut NENs and that the current threshold for classifying G1/G2 tumours should be revised from 2 to 5%.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
3.3
作者：
DONHUIJSEN, K;SCHMIDT, U;BUDACH, V
通讯作者：
BUDACH, V
影响因子：
11.5
作者：
Furlan, D;Cerutti, R;Capella, C
通讯作者：
Capella, C
影响因子：
3.5
作者：
Goodell, Pamela P.;Krasinskas, Alyssa M.;Hartman, Douglas J.
通讯作者：
Hartman, Douglas J.
DOI：
10.1007/bf02890294
发表时间：
1984-01-01
期刊：
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY
影响因子：
--
作者：
PAULUS, G;LI, XH;BUYSSENS, N
通讯作者：
BUYSSENS, N