Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
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严重急性呼吸综合征冠状病毒 2 感染中低炎症细胞因子水平的早期血浆白细胞介素 37 反应与良性临床结果之间的相关性。
DOI：
10.1093/infdis/jiaa713
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发表时间：
2021-02-24
期刊：
影响因子：
--
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Li A;Ling Y;Song Z;Cheng X;Ding L;Jiang R;Fu W;Liu Y;Hu H;Yuan S;Chen J;Zhu C;Fan J;Wang J;Jin Y;Zhang M;Zhu L;Sun P;Zhang L;Qin R;Zhang W;Qiu C;Shen Y;Zhang L;Shi Z;Zhao C;Zhu T;Lu H;Zhang X;Xu J
The immune protective mechanisms during severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection remain to be deciphered for the development of an effective intervention approach. We examined early responses of interleukin 37 (IL-37), a powerful anti-inflammatory cytokine, in 254 SARS-CoV-2–infected patients before any clinical intervention and determined its correlation with clinical prognosis. Our results demonstrated that SARS-CoV-2 infection causes elevation of plasma IL-37. Higher early IL-37 responses were correlated with earlier viral RNA negative conversion, chest computed tomographic improvement, and cough relief, consequently resulted in earlier hospital discharge. Further assays showed that higher IL-37 was associated with lower interleukin 6 and interleukin 8 (IL-8) and higher interferon α responses and facilitated biochemical homeostasis. Low IL-37 responses predicted severe clinical prognosis in combination with IL-8 and C-reactive protein. In addition, we observed that IL-37 administration was able to attenuate lung inflammation and alleviate respiratory tissue damage in human angiotensin-converting enzyme 2–transgenic mice infected with SARS-CoV-2. Overall, we found that IL-37 plays a protective role by antagonizing inflammatory responses while retaining type I interferon, thereby maintaining the functionalities of vital organs. IL-37, IL-8, and C-reactive protein might be formulated as a precise prediction model for screening severe clinical cases and have good value in clinical practice. Early plasma interleukin 37 (IL-37) responses is correlated with benign clinical outcomes in coronavirus disease 2019, and IL-37 administration attenuates lung inflammation in human angiotensin-converting enzyme 2–transgenic mice infected with severe acute respiratory syndrome coronavirus 2.
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