Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda.
Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda.
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功能神经系统障碍的神经影像学：现场和研究议程。
DOI：
10.1016/j.nicl.2021.102623
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Aybek S
中科院分区：
文献类型：
--
作者：
Perez DL;Nicholson TR;Asadi-Pooya AA;Bègue I;Butler M;Carson AJ;David AS;Deeley Q;Diez I;Edwards MJ;Espay AJ;Gelauff JM;Hallett M;Horovitz SG;Jungilligens J;Kanaan RAA;Tijssen MAJ;Kozlowska K;LaFaver K;LaFrance WC Jr;Lidstone SC;Marapin RS;Maurer CW;Modirrousta M;Reinders AATS;Sojka P;Staab JP;Stone J;Szaflarski JP;Aybek S
第一次功能性神经疾病 (FND) 神经影像工作组会议。强调 FND 队列特征在脑成像研究中的重要性。详细介绍了迄今为止 FND 神经影像研究中所采用的方法。提出的研究议程旨在明确阐明 FND 的神经回路。关于让 FND 研究人员加入 ENIGMA 联盟的讨论正在进行中。功能性神经系统疾病（FND）引起了早期临床神经科学领导者的极大兴趣。 20 世纪，神经病学和精神病学逐渐分离，使得 FND 成为一种边缘疾病。幸运的是，随着人们越来越认识到 FND 很普遍并使用“规则”检查体征进行诊断，过去二十年出现了复兴。并行使用科学工具来弥合大脑结构与功能之间的关系有助于完善一个综合的生物心理社会框架，通过该框架来概念化 FND。特别是，越来越多使用各种方法的高质量神经影像学研究揭示了 FND 的新兴病理生理学。这种新的科学兴趣与加强的跨学科合作同时发生，结合心理和物理治疗的新护理模式以及支持该领域知识传播的新的多学科 FND 协会的创建就表明了这一点。在此背景下，本文总结了 2020 年 6 月 17 日虚拟举行的首届国际 FND 神经影像工作组会议的成果，该会议旨在评估该领域神经影像研究的状况并促进大规模合作。我们首先简要总结 FND 的神经回路模型，然后详细介绍迄今为止在 FND 核心内容领域中使用的研究方法：队列特征；对照组的考虑因素；基于任务的功能神经影像学；静息态网络；结构神经影像学；症状严重程度和患病风险的生物标志物；以及治疗反应和预后的预测因素。最后，我们概述了一个以神经影像为重点的研究议程，以阐明 FND 的病理生理学，并帮助开发新颖的生物学和心理学治疗方法。
1st Neuroimaging Workgroup Meeting in Functional Neurological Disorder (FND). Underscores the importance of FND cohort characterization in brain imaging research. Details methodological approaches taken in FND neuroimaging research to date. Research agenda proposed to definitely elucidate the neural circuitry of FND. Discussions underway regarding having FND researchers join the ENIGMA consortium. Functional neurological disorder (FND) was of great interest to early clinical neuroscience leaders. During the 20th century, neurology and psychiatry grew apart – leaving FND a borderland condition. Fortunately, a renaissance has occurred in the last two decades, fostered by increased recognition that FND is prevalent and diagnosed using “rule-in” examination signs. The parallel use of scientific tools to bridge brain structure - function relationships has helped refine an integrated biopsychosocial framework through which to conceptualize FND. In particular, a growing number of quality neuroimaging studies using a variety of methodologies have shed light on the emerging pathophysiology of FND. This renewed scientific interest has occurred in parallel with enhanced interdisciplinary collaborations, as illustrated by new care models combining psychological and physical therapies and the creation of a new multidisciplinary FND society supporting knowledge dissemination in the field. Within this context, this article summarizes the output of the first International FND Neuroimaging Workgroup meeting, held virtually, on June 17th, 2020 to appraise the state of neuroimaging research in the field and to catalyze large-scale collaborations. We first briefly summarize neural circuit models of FND, and then detail the research approaches used to date in FND within core content areas: cohort characterization; control group considerations; task-based functional neuroimaging; resting-state networks; structural neuroimaging; biomarkers of symptom severity and risk of illness; and predictors of treatment response and prognosis. Lastly, we outline a neuroimaging-focused research agenda to elucidate the pathophysiology of FND and aid the development of novel biologically and psychologically-informed treatments.
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影响因子：
3.7
作者：
Aybek S;Nicholson TR;O'Daly O;Zelaya F;Kanaan RA;David AS
通讯作者：
David AS
影响因子：
4.2
作者：
Allendorfer, Jane B.;Nenert, Rodolphe;Szaflarski, Jerzy P.
通讯作者：
Szaflarski, Jerzy P.
影响因子：
4.8
作者：
Chee, MWL;Venkatraman, V;Siong, SC
通讯作者：
Siong, SC
影响因子：
2.6
作者：
Begue, Indrit;Blakemore, Rebekah;Vuilleumier, Patrik
通讯作者：
Vuilleumier, Patrik
DOI：
10.1176/appi.neuropsych.19120354
发表时间：
2021-06-01
影响因子：
2.9
作者：
Baslet, Gaston;Bajestan, Sepideh N.;LaFrance, W. Curt, Jr.
通讯作者：
LaFrance, W. Curt, Jr.