Emotion-motion interactions in conversion disorder: an FMRI study.
Emotion-motion interactions in conversion disorder: an FMRI study.
复制标题
DOI：
10.1371/journal.pone.0123273
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
David AS
中科院分区：
文献类型：
--
作者：
Aybek S;Nicholson TR;O'Daly O;Zelaya F;Kanaan RA;David AS
评估运动转换障碍（CD）患者负面情绪内隐加工的神经相关因素。事件相关的功能磁共振成像任务完成了12个电机CD患者和14个匹配的健康对照使用标准化刺激的面孔与恐惧和悲伤的情绪表达相比，面对中性的表情。对刺激的敏感性的时间变化也在两组中进行了建模和测试。我们发现增加杏仁核激活CD的负面情绪相比，健康对照组的兴趣区分析，这持续随着时间的推移与以前的研究结果一致，使用情绪范式。此外，在全脑分析过程中，我们发现CD患者对恐惧的“冻结反应”（导水管周围灰质）以及自我意识和运动控制（扣带回和辅助运动区）的区域的激活显着增加。与健康对照组相比，CD患者对恐惧刺激的反应幅度随时间推移而增加，表明情绪调节异常（习惯化/敏感化失败）。CD患者还激活了中脑和额叶结构，这些结构可以反映对包括威胁性刺激在内的负面刺激的异常行为运动反应。这表明在CD中存在一种将情绪与运动功能障碍联系起来的机制。
To evaluate the neural correlates of implicit processing of negative emotions in motor conversion disorder (CD) patients. An event related fMRI task was completed by 12 motor CD patients and 14 matched healthy controls using standardised stimuli of faces with fearful and sad emotional expressions in comparison to faces with neutral expressions. Temporal changes in the sensitivity to stimuli were also modelled and tested in the two groups. We found increased amygdala activation to negative emotions in CD compared to healthy controls in region of interest analyses, which persisted over time consistent with previous findings using emotional paradigms. Furthermore during whole brain analyses we found significantly increased activation in CD patients in areas involved in the ‘freeze response’ to fear (periaqueductal grey matter), and areas involved in self-awareness and motor control (cingulate gyrus and supplementary motor area). In contrast to healthy controls, CD patients exhibited increased response amplitude to fearful stimuli over time, suggesting abnormal emotional regulation (failure of habituation / sensitization). Patients with CD also activated midbrain and frontal structures that could reflect an abnormal behavioral-motor response to negative including threatening stimuli. This suggests a mechanism linking emotions to motor dysfunction in CD.
登录
查看更多内容
影响因子：
5.7
作者：
Diedrichsen, J;Shadmehr, R
通讯作者：
Shadmehr, R
影响因子：
5.6
作者：
Bakvis, Patricia;Spinhoven, Philip;Roelofs, Karin
通讯作者：
Roelofs, Karin
影响因子：
6.9
作者：
Demenescu, L. R.;Renken, R.;Aleman, A.
通讯作者：
Aleman, A.
影响因子：
2.6
作者：
Bakvis, Patricia;Spinhoven, Philip;Roelofs, Karin
通讯作者：
Roelofs, Karin
影响因子：
5
作者：
Maizels, Morris;Aurora, Sheena;Heinricher, Mary
通讯作者：
Heinricher, Mary