Biosensor diagnosis of urinary tract infections: a path to better treatment?
Biosensor diagnosis of urinary tract infections: a path to better treatment?
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DOI：
10.1016/j.tips.2011.03.001
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发表时间：
2011-06
影响因子：
13.8
通讯作者：
Liao JC
中科院分区：
文献类型：
--
作者：
Mach KE;Wong PK;Liao JC
尿路感染（UTI）是最常见的细菌感染之一，并造成重大的医疗负担。标准的基于培养的UTI诊断通常会延迟两到三天。在缺乏明确的微生物学诊断的情况下，医生经常开始经验性的广谱抗生素治疗，这导致了耐药病原体的出现。生物传感器正在成为传染病的强大诊断平台。类似于血糖传感器如何彻底改变糖尿病的管理和怀孕测试现在在家里进行，生物传感器有望显着改善UTI诊断。生物传感器适合与微流体技术集成用于护理点应用。本文综述了用于尿路感染诊断的生物传感器技术，包括病原体鉴定和抗菌药物敏感性测试以及生物传感器技术从实验室到床边的翻译障碍。
Urinary tract infection (UTI) is among the most common bacterial infections and poses a significant healthcare burden. The standard culture-based diagnosis of UTI has a typical delay of two to three days. In the absence of definitive microbiological diagnosis at the point of care, physicians frequently initiate empirical broad-spectrum antibiotic treatment, which has contributed to the emergence of resistant pathogens. Biosensors are emerging as a powerful diagnostic platform for infectious diseases. Similar to how blood glucose sensors revolutionized the management of diabetes and pregnancy tests are now conducted at home, biosensors are poised to significantly improve UTI diagnosis. Biosensors are amenable to integration with microfluidic technology for point-of-care applications. This review focuses on promising biosensor technology for UTI diagnosis, including pathogen identification and antimicrobial susceptibility testing and hurdles in the translation of biosensor technology from bench to bedside.
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