Modifications of masticatory behavior after trigeminal deafferentation in the rabbit
Modifications of masticatory behavior after trigeminal deafferentation in the rabbit
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家兔三叉神经传入神经阻滞后咀嚼行为的改变
DOI：
10.1007/bf00247360
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发表时间：
2004
影响因子：
2
通讯作者：
Toshifumi Morimoto
中科院分区：
文献类型：
--
作者：
Tsuyoshi Inoue;Takafumi Kato;Yuji Masuda;Takashi Nakamura;Y. Kawamura;Toshifumi Morimoto
本实验采用家兔双侧三叉神经传入阻滞，观察口面神经传入对咀嚼时下颌运动模式的调节作用。双侧上颌神经和下牙槽神经联合切断后，动物在术后第1周内不能自行进食。然而，当实验人员将食物放入口中时，它们可以咀嚼和吞咽。咀嚼时下颌运动模式和咀嚼肌肌电活动受传入神经阻滞的影响。这些改变包括：1）动力相下颌骨水平位移减小，2）最大张口度减小，3）动力相咬合不充分（或最小张口度的增加），4）颌运动的不规则模式，5）促进咀嚼速率，6）在咀嚼顺序（从接受食物到吞咽的过程）中咀嚼周期的数量增加，和7）下颌闭合肌肉活动减少。研究结果表明，三叉神经感觉支的传入神经阻滞降低咀嚼力。另一方面，由于眶下神经和颏神经的双侧切断，在面部皮肤感觉中断的动物中未观察到显著变化。因此，口内感觉而不是口外感觉可能对咀嚼时咀嚼力和下颌运动的调节很重要。咀嚼过程中的下颌运动进行了分析，无论是双边消融的皮质咀嚼区（CMA）或双侧病变的腹后内侧核（VPM）的丘脑，以检查是否深刻的影响三叉神经传入神经通过经皮质回路产生。CMA或VPM损伤的动物表现出进食行为障碍，包括从口中掉落摄入的食物，咀嚼过程延长，咀嚼效率降低等。然而，咀嚼期间的下颌运动模式与术前基本相似。这些结果并不一定否认CMA的下颌运动的调节的贡献，但表明，通过CMA和丘脑VPM核的经皮质反馈回路将不主要负责咀嚼过程中的下颌运动的模式形成在兔子。通过经皮质环的感觉反馈可能间接促进脑干CPG的活动，从而促进咀嚼节律或使咀嚼序列顺利进行。
SummaryBilateral trigeminal deafferentation was performed in the rabbit in order to assess the role of orofacial inputs in regulation of the pattern of jaw movements during chewing. After bilateral combined section of the maxillary and inferior alveolar nerves, the animals did not eat food by themselves in the first postoperative week. However, they could chew and swallow when food was inserted into the mouth by an experimenter. The pattern of jaw movements and associated EMG activities of masticatory muscles during chewing were modulated remarkably by deafferentation. These modifications include 1) decrease in the horizontal excursions of the mandible at the power phase, 2) decrease in the maximum gape, 3) insufficient occlusion at the power phase (or increase in the minimum gape), 4) irregular patterns of jaw movements, 5) facilitation of the chewing rate, 6) increase in the number of chewing cycles in a masticatory sequence (the process from acceptance of food to swallowing), and 7) decrease in jaw-closing muscle activities. The findings indicate that deafferentation of the trigeminal sensory branches reduced masticatory force. On the other hand, no significant change was seen in the animals with disruption of cutaneous sensations of the face due to bilateral section of the infraorbital and mental nerves. Intraoral sensations rather than extraoral sensations may thus be important for regulation of masticatory force and jaw movements during chewing. Jaw movements during chewing were also analyzed in the animals with either bilateral ablation of the cortical masticatory area (CMA) or bilateral lesion of the ventral posteromedial nucleus (VPM) of the thalamus in order to examine whether profound effects of trigeminal deafferentation are produced via the transcortical loop. The animals with lesion of either the CMA or VPM demonstrated disturbances in feeding behavior, including the dropping of ingested food from the mouth, elongation of a masticatory process, reduction in the chewing efficiency, etc. However, the pattern of jaw movements during chewing were essentially similar to that in the preoperative period. These results do not necessarily deny a contribution of the CMA to regulation of jaw movements but suggest that the transcortical feedback loop via the CMA and thalamic VPM nucleus would not primarily be responsible for pattern formation of jaw movements during chewing in the rabbit. Probably, the sensory feedback via the transcortical loop may indirectly facilitate activities of the brain stem CPG, which facilitates the chewing rhythm or enables masticatory sequences to be conducted smoothly.
大鼠的三叉神经口腔感觉和摄入行为。
影响因子：
1.9
作者：
Jacquin,MF;Zeigler,HP
通讯作者：
Zeigler,HP