Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.
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DOI：
10.1016/j.biopsych.2011.02.024
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发表时间：
2011-09-15
影响因子：
10.6
通讯作者：
Gelernter, Joel
中科院分区：
文献类型：
--
作者：
Li, Dawei;Zhao, Hongyu;Gelernter, Joel
酒精脱氢酶1B基因（ADH 1B）被假设影响酒精依赖（AD）和滥用的易感性。据报道，ADH 1B基因的变体（rs 1229984或Arg 48 His;以前称为Arg（*1）和His（*2））与酒精和药物依赖率降低有关。关于rs 1229984（或rs 2066702）和物质依赖之间的关联，不同的研究产生了不确定的结果。本荟萃分析使用过去21年来来自英文和中文出版物的累积关联研究文献，旨在澄清相互矛盾的结果，并检查汇总数据是否提供了显着关联的新证据。基于大样本量（9，638例病例和9，517例对照）的结果表明，酒精依赖和滥用以及酒精诱导的肝脏疾病与等位基因（Arg vs. His）P值为1×10−36，随机效应模型下的比值比（OR）为2.06（1.84，2.31）。显性和隐性模型产生较大的OR值分别为2.17和3.05。当采用更严格的标准和亚组分析时，相关性仍然保持一致，并且在各个亚洲群体中最强（等位基因P = 7×10−42和OR = 2.24（1.99，2.51），显性和隐性模型的OR分别为2.16和4.11）。我们的研究结果为ADH 1B基因参与酒精依赖和滥用的发病机制以及多种族人群，特别是某些亚洲人群中的一些酒精诱导的医学疾病提供了进一步的有力证据。
The alcohol dehydrogenase 1B gene (ADH1B) is hypothesized to affect predisposition to alcohol dependence (AD) and abuse. A variant of the ADH1B gene (rs1229984 or Arg48His; previously referred to as Arg (*1) and His (*2)) has been reported to be associated with reduced rates of alcohol and drug dependence. Different studies have produced inconclusive results regarding association between rs1229984 (or rs2066702) and substance dependence. Using the cumulative association study literature from the past 21 years from both English and Chinese-language publications, this meta-analysis seeks to clarify the contradictory findings and to examine whether the aggregate data provide new evidence of significant association. The results, based on a large sample size (9,638 cases and 9,517 controls), suggested strong associations with alcohol dependence and abuse as well as alcohol-induced liver diseases, with an allelic (Arg vs. His) P value being 1×10−36 and odds ratio (OR) 2.06 (1.84, 2.31) under the random effects model. The dominant and recessive models produced larger ORs of 2.17 and 3.05, respectively. When more stringent criteria and sub-group analyses were imposed, the associations remained consistent, and were strongest in various Asian groups (allelic P = 7×10−42 and OR = 2.24 (1.99, 2.51) with ORs of 2.16 and 4.11 for dominant and recessive models, respectively). Our findings provide further strong evidence for the involvement of the ADH1B gene in the pathogenesis of alcohol dependence and abuse as well as for some alcohol-induced medical diseases in the multiple ethnic populations, in particular, in certain Asian populations.
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影响因子：
2.8
作者：
Chao, YC;Wang, SJ;Hsieh, TY
通讯作者：
Hsieh, TY
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
3.7
作者：
Drgon T;Zhang PW;Johnson C;Walther D;Hess J;Nino M;Uhl GR
通讯作者：
Uhl GR
影响因子：
3.5
作者：
Birley, Andrew J.;James, Michael R.;Whitfield, John B.
通讯作者：
Whitfield, John B.