Strain Differences of Interferon–Generating Capacity and Resistance in Toxoplasma–Infected Mice
Strain Differences of Interferon–Generating Capacity and Resistance in Toxoplasma–Infected Mice
复制标题
弓形虫感染小鼠干扰素产生能力和抵抗力的品系差异
作者：
T. Shirahata;A. Mori;H. Ishikawa;H. Goto
To explore a possible correlation between susceptibility to Toxoplasma and interferon (IFN)‐generating capacity in mice, we compared the levels of serum IFN induced by stimulation with Toxoplasma lysate antigen (TLA) in different strains of Toxoplasma‐infected and uninfected mice. Injection of TLA into five strains of mice with chronic Toxoplasma infection resulted in the release of considerable amounts of IFN into the circulation. Most of these IFN activities were acid labile and not neutralized by sheep antiserum against mouse IFN‐α/β, indicating that IFN‐γ was the dominant form produced in this system. In contrast, the majority of IFN induced in uninfected mice was characterized as IFN‐α/β by their acid stability and antigenicity. The response of IFN production in Toxoplasma‐infected and uninfected mice varied quantitatively depending on the mouse strains examined. C57BL/6 mice were found to be the best producers of both IFN‐α/β and IFN‐γ, while BALB/c mice were consistently poor producers of both IFN populations. A/J, DBA/2, and C3H/He mice could be roughly classified as intermediate producers of both IFN populations. C57BL/6 and C3H/He mice showed a significant prolongation of mean survival time following primary or secondary infection with Toxoplasma compared to that of BALB/c mice. However, there was no direct correlation between the susceptibility to Toxoplasma and the levels of serum IFN.
影响因子：
4.4
作者：
S. Sharma;J. M. Hofflin;J. Remington
通讯作者：
S. Sharma;J. M. Hofflin;J. Remington
鼠干扰素γ对鼠弓形虫病的作用。
DOI：
10.1093/infdis/150.6.961
发表时间：
1984
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
McCabe,RE;Luft,BJ;Remington,JS
通讯作者：
Remington,JS
干扰素-γ 体外和体内激活小鼠腹膜巨噬细胞。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Murray,HW;Spitalny,GL;Nathan,CF
通讯作者：
Nathan,CF